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Prime Medicine PRME

US equityMarket cap rank #3547
$3.65 −$0.25 (-6.41%)
Market open · Oct 8, 12:30 pm ET · After hours $3.88 -0.42%
Open$3.83
Prev close$3.90
Day range$3.58 – $3.90
Volume3.46M
Market cap$662.03M
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership76.1%-11.13 pts vs. prior quarter
Institutions holding226-5 vs. prior quarter
Insider trades (recent)40 buys / 10 sellsNet buying
ARK fund activity+206,310 sh1 recent transactions · last 21 Jul 2026
Short interest17.72% of floatDays to cover 12.3 · as of 15 Sep 2026
Short-sale volume share23.4%5-day average of daily volume

Short-sale volume as % of daily volume

6%14%23%31%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$2.28M (8 inflow days, 12 outflow days).

Net flow by order size, last 20 sessions

−$3.3MSuper+$971.0KBig+$838.5KMid+$1.3MSmall

Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.

The five largest holders on file together own 39.2% of shares outstanding.

Largest holders

  • David Liu11.38%
  • GV Management Company, LLC9.31%
  • Arch Venture Partners, L.P.6.89%
  • Bristol-Myers Squibb Company6.19%
  • BlackRock5.40%
  • ARK Investment Management LLC4.69%
  • State Street Global Advisors4.26%
  • Newpath Management, L.P.3.43%

By investor type

  • Mutual Fund32.83%
  • VC/PE Fund22.40%
  • Individual/Insider14.52%
  • Hedge Fund10.45%
  • Public Company8.96%
  • Private Company0.72%
  • Family Office/Trust0.46%
  • Government Pension Fund0.16%

Reported short interest has fallen from 19.23% to 17.72% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Recent institutional activity

HolderTypePeriodShare changeNew stake
Nuveen Asset Management LLC Insurance Company 2026/Q3 +245,007 0.1%
ARK Investment Management LLC Mutual Fund 2026/Q3 +2,101,919 4.7%
The Goldman Sachs Group, Inc. Public Company 2026/Q3 +2,029,275 1.3%
Citadel Advisors LLC Hedge Fund 2026/Q3 +1,718,185 1.2%
Leap Investments LP Mutual Fund 2026/Q3 +1,239,598 0.7%
State Street Global Advisors Mutual Fund 2026/Q3 +1,231,335 4.3%
BlackRock Mutual Fund 2026/Q3 +1,100,333 5.4%
Point72 Asset Management, L.P. Hedge Fund 2026/Q3 +533,553 0.3%
Goldman Sachs Asset Management, L.P. Mutual Fund 2026/Q3 +430,818 0.6%
Millennium Management LLC Hedge Fund 2026/Q3 +427,097 0.2%
Bank of America Corporation Public Company 2026/Q3 +404,331 0.6%
Alessandra Capital Management, LLC Family Office/Trust 2026/Q3 +241,093 0.4%
Jain Global LLC Hedge Fund 2026/Q3 +215,218 0.1%
Jupiter Fund Management Plc Mutual Fund 2026/Q3 +209,490 0.1%
Peak6 Group LLC Hedge Fund 2026/Q3 +208,057 0.1%

Institutional buy/sell activity by reporting period, largest moves first.

Insider transactions

DateInsiderTitleTransactionSharesPriceHeld after
4 Jun 2026 Robert Taylor Nelsen Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 Michael Kelly Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 Kaye Foster-Cheek Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 David Schenkein Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 Jeffrey Marrazzo Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 Wendy Chung Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
4 Jun 2026 Thomas Cahill Independent Director Other Derivative Acquisition +75,000 $3.06 75,000
25 Feb 2026 Allan Reine Chief Financial Officer Other Derivative Acquisition +1,300,000 $4.38 1,300,000
22 Feb 2026 Ann Lee Chief Technology Officer Other Derivative Acquisition +375,000 $3.34 375,000
22 Feb 2026 Carman Alenson Chief Accounting Officer & Interim CFO Other Derivative Acquisition +140,000 $3.34 140,000
31 Jul 2025 Robert Taylor Nelsen Independent Director Derivative Sale to Issuer -84,062 – –
31 Jul 2025 Robert Taylor Nelsen Independent Director Other Derivative Acquisition +84,062 $4.04 45,000
31 Jul 2025 Michael Kelly Independent Director Derivative Sale to Issuer -106,578 – –
31 Jul 2025 Michael Kelly Independent Director Other Derivative Acquisition +106,578 $4.04 45,000
31 Jul 2025 Kaye Foster-Cheek Independent Director Derivative Sale to Issuer -106,578 – –
31 Jul 2025 Kaye Foster-Cheek Independent Director Other Derivative Acquisition +106,578 $4.04 45,000
31 Jul 2025 David Schenkein Independent Director Derivative Sale to Issuer -84,062 – –
31 Jul 2025 David Schenkein Independent Director Other Derivative Acquisition +84,062 $4.04 45,000
31 Jul 2025 Ann Lee Chief Technology Officer Derivative Sale to Issuer -361,990 – –
31 Jul 2025 Ann Lee Chief Technology Officer Other Derivative Acquisition +361,990 $4.04 180,995

From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 32,132,218 17.7% 12.3
31 Aug 2026 36,761,940 20.3% 13.1
14 Aug 2026 35,022,290 19.3% 13.8
31 Jul 2026 35,003,578 19.4% 12.9
15 Jul 2026 33,536,516 18.6% 6.7
30 Jun 2026 34,729,797 19.2% 9.1

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