开盘$51.79
昨收$51.78
当日区间$50.76 – $54.64
成交量1.62M
市值$2.79B
市盈率（TTM）85.3
股息率–
股权结构与仓位
谁在持有、谁在做空，以及大资金的流向
机构持股比例110.5%-0.30 个百分点，较上季度
持仓机构数382+1 ，较上季度
内部人近期交易24次买入 / 26次卖出净卖出
空头持仓比例10.23% 占流通股回补天数 9.5 · 截至 15 Oct 2026
卖空成交量占比18.5%近5日成交量平均占比
卖空成交量占当日成交量比例
大单净流入，近20个交易日
大单买入减卖出的净额（美元）。该窗口期内：−$416.6K（9个净流入日，11个净流出日）。
按单量净流入，近20个交易日
超大单/大单近似机构级别交易；中单/小单近似散户级别交易。各档买入减卖出净额，按窗口期累计。
已披露的前五大股东合计持有36.4%的流通股。
最大股东
按投资者类型
过去6次双周报告中（31 Jul 2026至15 Oct 2026），空头持仓占流通股比例已从8.66%升至10.23%。
近期机构持仓变动
| 股东 | 类型 | 期间 | 持股变动 | 新持股比例 |
|---|---|---|---|---|
| Nuveen Asset Management LLC | Insurance Company | 2026/Q3 | +481,684 | 1.0% |
| Congress Asset Management Company, LLP | Mutual Fund | 2026/Q3 | +1,409,377 | 5.7% |
| Next Century Growth Investors LLC | Mutual Fund | 2026/Q3 | +459,805 | 1.2% |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Mutual Fund | 2026/Q3 | +392,196 | 1.0% |
| Balyasny Asset Management L.P. | Hedge Fund | 2026/Q3 | +336,547 | 0.7% |
| BlackRock | Mutual Fund | 2026/Q3 | +326,882 | 15.8% |
| Point72 Asset Management, L.P. | Hedge Fund | 2026/Q3 | +279,336 | 0.9% |
| AQR Capital Management | Hedge Fund | 2026/Q3 | +231,876 | 0.5% |
| Loomis, Sayles & Company L.P. | Mutual Fund | 2026/Q3 | +224,792 | 2.3% |
| William Blair Investment Management, LLC | Mutual Fund | 2026/Q3 | +160,146 | 3.9% |
| D. E. Shaw & Co., L.P. | Hedge Fund | 2026/Q3 | +156,663 | 0.9% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +141,845 | 6.4% |
| The Glenmede Trust Company, National Association | Mutual Fund | 2026/Q3 | +124,824 | 0.3% |
| Lisanti Capital Growth, LLC | Mutual Fund | 2026/Q3 | +120,380 | 0.2% |
| Two Sigma Investments, LP | Hedge Fund | 2026/Q3 | +95,970 | 1.1% |
按报告期列出的机构买卖动态，变动幅度从大到小排列。
内部人交易
| 日期 | 内部人 | 职位 | 交易类型 | 股数 | 价格 | 交易后持股 |
|---|---|---|---|---|---|---|
| 11 Aug 2026 | Kevin McLaughlin | Independent Director | Derivative Exercise and Sale | -7,000 | $44.53 | 18,300 |
| 2 Aug 2026 | Michael Halpin | Chief Operating Officer | Derivative Exercise and Sale | -10,000 | $46.84 | 16,394 |
| 29 Jul 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Derivative Exercise and Sale | -4,500 | $48.90 | 1,078 |
| 25 Jun 2026 | Jonathan Hopper | Chief Medical Officer | Derivative Exercise and Sale | -10,000 | $45.00 | 75,753 |
| 25 Jun 2026 | Sean Flynn | Chief Legal Officer | Derivative Exercise and Sale | -15,000 | $45.64 | 1,647 |
| 25 Jun 2026 | Joseph Mara | Chief Financial Officer | Automatic Disposition | -5,000 | $44.75 | 16,009 |
| 25 Jun 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Automatic Disposition | -232 | $44.90 | 886 |
| 25 Jun 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Derivative Exercise and Sale | -2,500 | $44.90 | 886 |
| 17 Jun 2026 | Michael Halpin | Chief Operating Officer | Derivative Exercise and Sale | -10,000 | $40.24 | 16,248 |
| 17 Jun 2026 | Sean Flynn | Chief Legal Officer | Derivative Exercise and Sale | -15,000 | $40.21 | 1,647 |
| 1 Jun 2026 | Jonathan Hopper | Chief Medical Officer | Derivative Exercise and Sale | -4,375 | $35.00 | 75,753 |
| 12 May 2026 | Kevin McLaughlin | Independent Director | Derivative Exercise and Sale | -7,000 | $32.83 | 18,300 |
| 12 May 2026 | Kevin McLaughlin | Independent Director | Other Derivative Acquisition | +7,000 | $13.05 | 14,000 |
| 10 May 2026 | Paul Wotton | Independent Director | Open Market Disposition | -10,000 | $33.05 | 18,802 |
| 6 May 2026 | Joseph Mara | Chief Financial Officer | Automatic Disposition | -5,000 | $40.50 | 21,009 |
| 6 May 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Intent to Sell (Form 144) | -1,422 | $40.50 | – |
| 6 May 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Automatic Disposition | -4,855 | $40.50 | 1,118 |
| 5 May 2026 | Jonathan Siegal | Principal Accounting Officer, VP & Corporate Controller | Intent to Sell (Form 144) | -3,433 | $38.00 | – |
| 28 Apr 2026 | Kevin McLaughlin | Independent Director | Other Derivative Acquisition | +3,200 | – | 3,200 |
| 28 Apr 2026 | Kevin McLaughlin | Independent Director | Other Derivative Acquisition | +8,000 | $33.43 | 8,000 |
数据来自Form 4/Form 144申报文件。负数为减持（出售、赠予或代扣税款股份），正数为增持。
空头持仓（按报告期）
| 报告日期 | 空头股数 | 占流通股比例 | 回补天数 |
|---|---|---|---|
| 15 Oct 2026 | 5,238,041 | 10.2% | 9.5 |
| 30 Sep 2026 | 5,202,417 | 10.2% | 9.6 |
| 15 Sep 2026 | 5,483,102 | 10.7% | 12.1 |
| 31 Aug 2026 | 4,759,226 | 9.3% | 9.0 |
| 14 Aug 2026 | 4,723,479 | 9.2% | 11.5 |
| 31 Jul 2026 | 4,433,745 | 8.7% | 8.5 |
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