股票 › PTGX
主角治疗 PTGX
美股市值排名 #1585
$132.04 −$3.22 (-2.38%)
休市 · Nov 6, 8:10 pm ET · 最新盘后价 $132.04 0.00%
开盘$135.26
昨收$135.26
当日区间$128.00 – $138.40
成交量972.9K
市值$8.54B
市盈率（TTM）128.2
股息率–
股权结构与仓位
谁在持有、谁在做空，以及大资金的流向
机构持股比例119.6%-0.80 个百分点，较上季度
持仓机构数444+16 ，较上季度
内部人近期交易17次买入 / 33次卖出净卖出
空头持仓比例15.91% 占流通股回补天数 12.0 · 截至 15 Oct 2026
卖空成交量占比25.0%近5日成交量平均占比
卖空成交量占当日成交量比例
大单净流入，近20个交易日
大单买入减卖出的净额（美元）。该窗口期内：+$7.06M（12个净流入日，8个净流出日）。
按单量净流入，近20个交易日
超大单/大单近似机构级别交易；中单/小单近似散户级别交易。各档买入减卖出净额，按窗口期累计。
已披露的前五大股东合计持有43.9%的流通股。
最大股东
按投资者类型
过去6次双周报告中（31 Jul 2026至15 Oct 2026），空头持仓占流通股比例已从11.73%升至15.91%。
近期机构持仓变动
| 股东 | 类型 | 期间 | 持股变动 | 新持股比例 |
|---|---|---|---|---|
| BlackRock | Mutual Fund | 2026/Q3 | +528,468 | 15.9% |
| T. Rowe Price Group, Inc. | Mutual Fund | 2026/Q3 | +484,165 | 3.3% |
| Putnam LLC | Mutual Fund | 2026/Q3 | +382,425 | 0.7% |
| Alyeska Investment Group, L.P. | Hedge Fund | 2026/Q3 | +296,101 | 1.4% |
| Stephens Investment Management Group, LLC | Mutual Fund | 2026/Q3 | +281,832 | 0.4% |
| Lord, Abbett & Co. LLC | Mutual Fund | 2026/Q3 | +235,535 | 0.6% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +204,805 | 5.1% |
| Neuberger Berman Investment Advisers LLC | Mutual Fund | 2026/Q3 | +203,954 | 0.5% |
| Vanguard Portfolio Management, LLC | Mutual Fund | 2026/Q3 | +148,087 | 5.6% |
| Macquarie Investment Management Business Trust | Mutual Fund | 2026/Q3 | +141,081 | 0.2% |
| Invesco Ltd. | Mutual Fund | 2026/Q3 | +134,843 | 2.6% |
| Voya Investment Management LLC | Mutual Fund | 2026/Q3 | +117,235 | 0.9% |
| BNP Paribas Financial Markets SNC | Private Company | 2026/Q3 | +106,942 | 0.5% |
| Catalio Capital Management, LP | VC/PE Fund | 2026/Q3 | +106,799 | 0.2% |
| ClearBridge Investments, LLC | Mutual Fund | 2026/Q3 | +103,515 | 1.1% |
按报告期列出的机构买卖动态，变动幅度从大到小排列。
内部人交易
| 日期 | 内部人 | 职位 | 交易类型 | 股数 | 价格 | 交易后持股 |
|---|---|---|---|---|---|---|
| 29 Sep 2026 | Asif Ali | Chief Financial Officer | Derivative Exercise and Sale | -58,629 | $141.78 | 2,569 |
| 9 Sep 2026 | Dinesh Patel | CEO, President, Secretary & Director | Derivative Exercise and Sale | -125,000 | $146.18 | 286,926 |
| 2 Sep 2026 | Dinesh Patel | CEO, President, Secretary & Director | Other Disposition | -510 | – | 286,926 |
| 10 Aug 2026 | Dinesh Patel | CEO, President, Secretary & Director | Derivative Exercise and Sale | -100,000 | $149.11 | 287,436 |
| 22 Jun 2026 | William Waddill | Independent Director | Derivative Exercise and Sale | -9,000 | $117.94 | 5,130 |
| 9 Jun 2026 | William Waddill | Independent Director | Derivative Exercise and Sale | -9,000 | $107.68 | 5,130 |
| 28 May 2026 | William Waddill | Independent Director | Derivative Exercise and Sale | -9,000 | $99.64 | 5,130 |
| 11 May 2026 | Dinesh Patel | CEO, President, Secretary & Director | Derivative Exercise and Sale | -75,000 | $100.12 | 287,436 |
| 7 May 2026 | Bryan Giraudo | Independent Director | Open Market Disposition | -23,130 | $100.07 | 10,000 |
| 6 May 2026 | Bryan Giraudo | Independent Director | Derivative Exercise and Sale | -36,000 | $100.14 | 10,000 |
| 22 Apr 2026 | Dinesh Patel | CEO, President, Secretary & Director | Other Disposition | -1,460 | – | 287,436 |
| 19 Apr 2026 | Asif Ali | Chief Financial Officer | Open Market Disposition | -1,750 | $105.47 | 2,569 |
| 25 Mar 2026 | Harold Selick | Independent Chairperson | Derivative Exercise and Sale | -24,000 | $105.00 | 58,150 |
| 25 Mar 2026 | Arturo Molina | Chief Medical Officer | Derivative Exercise and Sale | -15,000 | $104.79 | 13,637 |
| 25 Mar 2026 | Asif Ali | Chief Financial Officer | Derivative Exercise and Sale | -24,765 | $104.24 | 4,319 |
| 24 Mar 2026 | Dinesh Patel | CEO, President, Secretary & Director | Derivative Exercise and Sale | -54,700 | $101.00 | 288,896 |
| 22 Mar 2026 | Dinesh Patel | CEO, President, Secretary & Director | Other Disposition | -50,000 | – | 288,896 |
| 16 Feb 2026 | Lewis Williams | Independent Director | Derivative Exercise and Sale | -18,000 | $82.42 | 5,130 |
| 5 Feb 2026 | William Waddill | Independent Director | Derivative Exercise and Sale | -20,000 | $83.68 | 5,130 |
| 26 Jan 2026 | Arturo Molina | Chief Medical Officer | Intent to Sell (Form 144) | -5,000 | $82.00 | – |
数据来自Form 4/Form 144申报文件。负数为减持（出售、赠予或代扣税款股份），正数为增持。
空头持仓（按报告期）
| 报告日期 | 空头股数 | 占流通股比例 | 回补天数 |
|---|---|---|---|
| 15 Oct 2026 | 10,297,224 | 15.9% | 12.0 |
| 30 Sep 2026 | 9,345,382 | 14.4% | 11.5 |
| 15 Sep 2026 | 8,140,194 | 12.6% | 15.1 |
| 31 Aug 2026 | 7,712,543 | 11.9% | 15.3 |
| 14 Aug 2026 | 7,791,795 | 12.0% | 16.4 |
| 31 Jul 2026 | 7,543,109 | 11.7% | 14.2 |
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