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马德里格尔制药 MDGL

美股市值排名 #1510生物科技

$399.63 −$0.47 (-0.12%)

休市 · Nov 6, 8:10 pm ET · 最新盘后价 $403.28 +0.91%

开盘$400.00

昨收$400.10

当日区间$378.28 – $401.61

成交量1.09M

市值$9.28B

市盈率（TTM）–

股息率–

股权结构与仓位

谁在持有、谁在做空，以及大资金的流向

机构持股比例107.1%-0.52 个百分点，较上季度

持仓机构数514+11 ，较上季度

内部人近期交易29次买入 / 21次卖出净买入

空头持仓比例9.50% 占流通股回补天数 7.2 · 截至 15 Oct 2026

卖空成交量占比7.5%近5日成交量平均占比

卖空成交量占当日成交量比例

大单净流入，近20个交易日

大单买入减卖出的净额（美元）。该窗口期内：−$11.00M（10个净流入日，10个净流出日）。

按单量净流入，近20个交易日

超大单/大单近似机构级别交易；中单/小单近似散户级别交易。各档买入减卖出净额，按窗口期累计。

已披露的前五大股东合计持有40.0%的流通股。

最大股东

Baker Bros. Advisors LP9.28%
RTW Investments, LP8.63%
Janus Henderson Group plc8.38%
Avoro Capital Advisors LLC7.94%
Paulson & Co. Inc.5.80%
BlackRock5.20%
Vanguard Capital Management, LLC4.14%
Wellington Management Group3.57%

按投资者类型

Mutual Fund54.82%
Hedge Fund41.39%
Private Company6.07%
Individual/Insider5.25%
Public Company2.58%
Government Pension Fund0.98%
Sovereign Wealth Fund0.94%
Insurance Company0.19%

过去6次双周报告中（31 Jul 2026至15 Oct 2026），空头持仓占流通股比例已从8.51%升至9.50%。

近期机构持仓变动

股东	类型	期间	持股变动	新持股比例
William Sibold	Individual/Insider	2026/Q3	+146,017	0.7%
UBS Asset Management	Mutual Fund	2026/Q3	+292,536	1.9%
Jane Street Group, LLC	Private Company	2026/Q3	+155,703	0.8%
Holocene Advisors, LP	Hedge Fund	2026/Q3	+152,924	0.7%
Susquehanna International Group, LLP	Private Company	2026/Q3	+142,147	0.7%
Columbia Management Investment Advisers, LLC	Mutual Fund	2026/Q3	+133,024	1.0%
Wellington Management Group	Mutual Fund	2026/Q3	+130,756	3.6%
Assenagon Asset Management S.A.	Mutual Fund	2026/Q3	+108,181	0.5%
ClearBridge Investments, LLC	Mutual Fund	2026/Q3	+84,878	0.5%
Hudson River Trading LLC	Private Company	2026/Q3	+84,634	0.4%
Marshall Wace LLP	Hedge Fund	2026/Q3	+79,957	0.4%
Balyasny Asset Management L.P.	Hedge Fund	2026/Q3	+79,011	0.3%
Allspring Global Investments, LLC	Mutual Fund	2026/Q3	+66,470	0.3%
AllianceBernstein	Mutual Fund	2026/Q3	+64,011	0.8%
Citadel Advisors LLC	Hedge Fund	2026/Q3	+53,390	2.2%

按报告期列出的机构买卖动态，变动幅度从大到小排列。

内部人交易

日期	内部人	职位	交易类型	股数	价格	交易后持股
27 Sep 2026	Paul Friedman	Former Director	Intent to Sell (Form 144)	-50,000	$516.56	–
10 Sep 2026	William Sibold	Chief Executive Officer	Automatic Disposition	-5,221	$546.38	154,327
8 Sep 2026	William Sibold	Chief Executive Officer	Open Market Disposition	-6,362	$542.55	154,327
16 Aug 2026	Shannon Kelley	Executive Vice President	Open Market Disposition	-664	$514.97	1,076
14 Aug 2026	John Reed	Director	Other Acquisition	+647	–	647
14 Aug 2026	John Reed	Director	Other Derivative Acquisition	+1,078	$507.56	1,078
19 Jul 2026	William Sibold	Chief Executive Officer	Derivative Exercise and Sale	-2,500	$555.05	153,410
16 Jul 2026	William Sibold	Chief Executive Officer	Derivative Exercise and Retained	+47,500	–	153,410
16 Jun 2026	Julian Baker	Independent Chairperson	Other Acquisition	+454	–	454
16 Jun 2026	Julian Baker	Independent Chairperson	Other Derivative Acquisition	+766	$499.86	766
16 Jun 2026	Jacqualyn Fouse	Independent Director	Other Acquisition	+454	–	901
16 Jun 2026	Jacqualyn Fouse	Independent Director	Other Derivative Acquisition	+766	$499.86	766
16 Jun 2026	Richard Levy	Independent Director	Other Acquisition	+454	–	454
16 Jun 2026	Richard Levy	Independent Director	Other Derivative Acquisition	+766	$499.86	766
16 Jun 2026	Rebecca Taub	Founder, Senior Scientific & Medical Advisor and Director	Other Acquisition	+454	–	11,634
16 Jun 2026	Rebecca Taub	Founder, Senior Scientific & Medical Advisor and Director	Other Derivative Acquisition	+766	$499.86	766
16 Jun 2026	James Daly	Independent Director	Other Acquisition	+454	–	454
16 Jun 2026	James Daly	Independent Director	Other Derivative Acquisition	+766	$499.86	766
16 Jun 2026	Daniel Brennan	Independent Director	Other Acquisition	+404	–	1,371
16 Jun 2026	Daniel Brennan	Independent Director	Other Derivative Acquisition	+681	$499.86	681

数据来自Form 4/Form 144申报文件。负数为减持（出售、赠予或代扣税款股份），正数为增持。

空头持仓（按报告期）

报告日期	空头股数	占流通股比例	回补天数
15 Oct 2026	2,194,545	9.5%	7.2
30 Sep 2026	2,396,369	10.4%	9.8
15 Sep 2026	2,254,423	9.8%	11.4
31 Aug 2026	2,240,575	9.7%	9.5
14 Aug 2026	2,025,404	8.8%	6.1
31 Jul 2026	1,965,849	8.5%	4.8

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