Vertex Pharmaceuticals VRTX
$547.09 +$4.59 (+0.85%)
Market closed · Nov 6, 8:10 pm ET · Last extended-hours $548.00 +0.17%
Open$531.53
Prev close$542.50
Day range$531.53 – $548.76
Volume1.27M
Market cap$138.71B
P/E (TTM)35.2
Dividend yield–
Ownership & positioning
Who holds it, who is betting against it, and where the big money is moving
Institutional ownership96.9%+0.00 pts vs. prior quarter
Institutions holding2,129+32 vs. prior quarter
Insider trades (recent)28 buys / 22 sellsNet buying
Short interest1.68% of floatDays to cover 3.4 · as of 15 Oct 2026
Short-sale volume share17.9%5-day average of daily volume
Short-sale volume as % of daily volume
Large-order net flow, last 20 sessions
Net of large-order buying minus selling, in USD. Over this window: −$45.25M (8 inflow days, 12 outflow days).
Net flow by order size, last 20 sessions
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 44.3% of shares outstanding.
Largest holders
By investor type
Reported short interest has risen from 1.55% to 1.68% of float over the last 6 biweekly reports (31 Jul 2026 to 15 Oct 2026).
Recent institutional activity
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Assenagon Asset Management S.A. | Mutual Fund | 2026/Q3 | +459,747 | 0.5% |
| Montrusco Bolton Investments Inc. | Mutual Fund | 2026/Q3 | +149,888 | 0.1% |
| Putnam LLC | Mutual Fund | 2026/Q3 | +2,737,137 | 1.1% |
| SG Americas Securities, LLC | Private Company | 2026/Q3 | +466,738 | 0.2% |
| AQR Capital Management | Hedge Fund | 2026/Q3 | +437,893 | 0.2% |
| Millennium Management LLC | Hedge Fund | 2026/Q3 | +437,587 | 0.2% |
| Hudson Bay Capital Management LP | Hedge Fund | 2026/Q3 | +345,440 | 0.2% |
| Invesco Capital Management LLC | Mutual Fund | 2026/Q3 | +323,793 | 2.9% |
| Victory Capital Management Inc. | Mutual Fund | 2026/Q3 | +284,631 | 0.9% |
| Jennison Associates LLC | Mutual Fund | 2026/Q3 | +258,471 | 1.2% |
| Marshall Wace LLP | Hedge Fund | 2026/Q3 | +226,839 | 0.2% |
| Assenagon Asset Management S.A. | Mutual Fund | 2026/Q3 | +222,316 | 0.3% |
| Pictet Asset Management Limited | Mutual Fund | 2026/Q3 | +201,686 | 0.2% |
| Sparinvest SA (Luxembourg) | Mutual Fund | 2026/Q3 | +196,334 | 0.1% |
| Susquehanna International Group, LLP | Private Company | 2026/Q3 | +185,692 | 0.1% |
Institutional buy/sell activity by reporting period, largest moves first.
Insider transactions
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 19 Oct 2026 | Daniel Brennan | Independent Director | Other Acquisition | +795 | $503.47 | 795 |
| 14 Oct 2026 | Bruce Sachs | Lead Independent Director | Other Derivative Acquisition | +92 | – | 15,865 |
| 14 Oct 2026 | Alan Garber | Independent Director | Other Derivative Acquisition | +29 | – | 95 |
| 7 Sep 2026 | Jasper van Grunsven | Executive VP & Chief Pain & New Product Planning Officer | Other Acquisition | +8,682 | – | 8,682 |
| 27 Aug 2026 | Kristen Ambrose | Chief Accounting Officer | Other Acquisition | +5,000 | – | 11,624 |
| 26 Aug 2026 | Bruce Sachs | Lead Independent Director | Other Disposition | -6,000 | – | 39,000 |
| 20 Jul 2026 | Amit Sachdev | Executive VP & Chief Patient and External Affairs Officer | Other Acquisition | +8,251 | – | 74,031 |
| 20 Jul 2026 | Ourania Tatsis | Executive VP & Chief Product Affairs Officer | Other Acquisition | +8,251 | – | 53,572 |
| 14 Jul 2026 | Bruce Sachs | Lead Independent Director | Other Derivative Acquisition | +99 | – | 15,772 |
| 14 Jul 2026 | Alan Garber | Independent Director | Other Derivative Acquisition | +31 | – | 65 |
| 1 Jul 2026 | Ourania Tatsis | Executive VP & Chief Product Affairs Officer | Automatic Disposition | -1,500 | $524.99 | 45,321 |
| 1 Jul 2026 | Duncan McKechnie | Executive Vice President | Automatic Disposition | -1,541 | $519.00 | 11,001 |
| 30 Jun 2026 | Joy Liu | EVP, Chief Legal Officer & Corporate Secretary | Automatic Disposition | -828 | $502.71 | 19,131 |
| 25 Jun 2026 | Carmen Bozic | Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer | Automatic Disposition | -596 | $482.50 | 15,337 |
| 17 Jun 2026 | Carmen Bozic | Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer | Automatic Disposition | -1,020 | $462.17 | 15,933 |
| 14 Jun 2026 | Carmen Bozic | Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer | Automatic Disposition | -4,062 | $450.00 | 16,953 |
| 4 Jun 2026 | Carmen Bozic | Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer | Automatic Disposition | -1,745 | $450.00 | 21,015 |
| 31 May 2026 | Joy Liu | EVP, Chief Legal Officer & Corporate Secretary | Automatic Disposition | -828 | $439.91 | 19,959 |
| 28 May 2026 | Carmen Bozic | Executive VP of Global Medicines Development & Medical Affairs and Chief Medical Officer | Automatic Disposition | -1,974 | $450.00 | 22,760 |
| 14 May 2026 | Mark Bunnage | Chief Scientific Officer | Automatic Disposition | -33 | $453.45 | 7,284 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
Short interest, by report
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Oct 2026 | 4,263,331 | 1.7% | 3.4 |
| 30 Sep 2026 | 4,503,200 | 1.8% | 4.2 |
| 15 Sep 2026 | 4,716,867 | 1.9% | 5.0 |
| 31 Aug 2026 | 4,659,749 | 1.8% | 4.5 |
| 14 Aug 2026 | 4,146,973 | 1.6% | 3.1 |
| 31 Jul 2026 | 3,942,936 | 1.6% | 3.0 |
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