Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$6.68M (7 inflow days, 13 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 35.4% of shares outstanding.
Reported short interest has risen from 11.21% to 12.59% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| EcoR1 Capital, LLC | Hedge Fund | 2026/Q3 | +3,174,519 | 8.9% |
| TCG Crossover Management, LLC | VC/PE Fund | 2026/Q3 | +2,895,304 | 8.1% |
| Sirenia Capital Management LP | Mutual Fund | 2026/Q3 | +2,495,777 | 7.0% |
| FMR | Mutual Fund | 2026/Q3 | +2,054,048 | 5.7% |
| Affinity Asset Advisors, LLC | Hedge Fund | 2026/Q3 | +2,032,012 | 5.7% |
| BlackRock | Mutual Fund | 2026/Q3 | +1,963,541 | 5.5% |
| Vanguard Capital Management, LLC | Mutual Fund | 2026/Q3 | +1,643,129 | 4.6% |
| Trails Edge Capital Partners, LP | Hedge Fund | 2026/Q3 | +1,514,000 | 4.2% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +1,512,896 | 4.2% |
| Janus Henderson Group plc | Mutual Fund | 2026/Q3 | +1,091,464 | 3.1% |
| Vestal Point Capital, LP | Hedge Fund | 2026/Q3 | +1,013,000 | 2.8% |
| Woodline Partners LP | Hedge Fund | 2026/Q3 | +917,176 | 2.6% |
| Sanofi | Public Company | 2026/Q3 | +821,917 | 2.3% |
| Morgan Stanley | Public Company | 2026/Q3 | +772,365 | 2.2% |
| 683 Capital Management, LLC | Hedge Fund | 2026/Q3 | +750,000 | 2.1% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 14 Sep 2026 | John Orwin | Director | Derivative Exercise and Retained | +1,300 | – | 17,995 |
| 1 Sep 2026 | J. Ware | Director | Derivative Exercise and Sale | -39,265 | $44.78 | 15,660 |
| 14 Aug 2026 | Paul Lizzul | Chief Medical Officer | Other Derivative Acquisition | +60,492 | – | 137,651 |
| 14 Aug 2026 | Daniel Faga | Chief Executive Officer | Other Derivative Acquisition | +193,575 | – | 440,485 |
| 14 Aug 2026 | Benjamin Stone | Chief Business Officer | Other Derivative Acquisition | +60,492 | – | 137,651 |
| 1 Aug 2026 | Paul Lizzul | Chief Medical Officer | Other Derivative Acquisition | +60,492 | – | 77,159 |
| 1 Aug 2026 | Daniel Faga | Chief Executive Officer | Other Derivative Acquisition | +193,576 | – | 387,156 |
| 1 Aug 2026 | Benjamin Stone | Chief Business Officer | Other Derivative Acquisition | +60,492 | – | 77,159 |
| 14 Jun 2026 | John Orwin | Director | Derivative Exercise and Retained | +6,030 | – | 16,695 |
| 14 Jun 2026 | John Schmid | Director | Derivative Exercise and Retained | +6,030 | – | 37,652 |
| 14 Jun 2026 | Dennis Fenton | Director | Derivative Exercise and Retained | +6,030 | – | 10,995 |
| 14 Jun 2026 | Magda Marquet | Director | Derivative Exercise and Retained | +6,030 | – | 15,960 |
| 14 Jun 2026 | J. Ware | Director | Derivative Exercise and Retained | +6,030 | – | 15,660 |
| 14 Jun 2026 | Rita Jain | Director | Derivative Exercise and Retained | +7,330 | – | 19,194 |
| 11 May 2026 | John Orwin | Director | Other Derivative Acquisition | +2,500 | – | 2,500 |
| 11 May 2026 | John Orwin | Director | Other Derivative Acquisition | +7,000 | $17.81 | 7,000 |
| 11 May 2026 | John Schmid | Director | Other Derivative Acquisition | +2,500 | – | 2,500 |
| 11 May 2026 | John Schmid | Director | Other Derivative Acquisition | +7,000 | $17.81 | 7,000 |
| 11 May 2026 | Dennis Fenton | Director | Other Derivative Acquisition | +2,500 | – | 2,500 |
| 11 May 2026 | Dennis Fenton | Director | Other Derivative Acquisition | +7,000 | $17.81 | 7,000 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 4,500,079 | 12.6% | 7.5 |
| 31 Aug 2026 | 4,030,463 | 11.3% | 7.2 |
| 14 Aug 2026 | 3,892,563 | 10.9% | 6.8 |
| 31 Jul 2026 | 3,957,023 | 11.3% | 4.6 |
| 15 Jul 2026 | 4,771,705 | 13.7% | 4.2 |
| 30 Jun 2026 | 3,912,589 | 11.2% | 4.8 |
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