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MBX Biosciences MBX

US equityMarket cap rank #2543Biotechnology
$58.54 +$0.03 (+0.05%)
Pre-market · Oct 6, 7:30 am ET · After hours $58.54 0.00%
Open$58.33
Prev close$58.51
Day range$56.42 – $59.26
Volume583.2K
Market cap$2.82B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership115.6%-1.95 pts vs. prior quarter
Institutions holding205+0 vs. prior quarter
Insider trades (recent)32 buys / 17 sellsNet buying
Short interest8.58% of floatDays to cover 11.4 · as of 15 Sep 2026
Short-sale volume share23.9%5-day average of daily volume

Short-sale volume as % of daily volume

17%22%27%32%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$6.34M (8 inflow days, 12 outflow days).

The five largest holders on file together own 49.6% of shares outstanding.

Largest holders

  • Frazier Life Sciences Management, LP13.81%
  • FMR11.05%
  • Wellington Management Group10.34%
  • New Enterprise Associates, Inc.7.51%
  • BlackRock6.90%
  • OrbiMed Advisors LLC6.38%
  • Paradigm Biocapital Advisors LP5.21%
  • NVP Associates, LLC4.44%

By investor type

  • Mutual Fund54.54%
  • VC/PE Fund37.09%
  • Hedge Fund21.02%
  • Individual/Insider2.74%
  • Public Company2.24%
  • Government Pension Fund0.24%
  • Insurance Company0.19%
  • Private Company0.17%

Reported short interest has fallen from 12.39% to 8.58% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 4,129,859 8.6% 11.4
31 Aug 2026 4,155,572 8.6% 10.1
14 Aug 2026 4,950,102 10.3% 11.2
31 Jul 2026 5,188,562 10.9% 8.5
15 Jul 2026 5,776,709 12.1% 6.2
30 Jun 2026 5,895,340 12.4% 5.3

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