Gyre Therapeutics GYRE
$4.76 +$0.75 (+18.70%)
Market closed · Nov 6, 8:10 pm ET · Last extended-hours $4.76 0.00%
Open$4.56
Prev close$4.01
Day range$4.08 – $4.79
Volume359.7K
Market cap$504.72M
P/E (TTM)–
Dividend yield–
Ownership & positioning
Who holds it, who is betting against it, and where the big money is moving
Institutional ownership68.6%-0.02 pts vs. prior quarter
Institutions holding74-2 vs. prior quarter
Insider trades (recent)23 buys / 24 sellsNet selling
Short interest1.82% of floatDays to cover 16.3 · as of 15 Oct 2026
Short-sale volume share16.9%5-day average of daily volume
Short-sale volume as % of daily volume
Large-order net flow, last 20 sessions
Net of large-order buying minus selling, in USD. Over this window: −$275.5K (5 inflow days, 15 outflow days).
Net flow by order size, last 20 sessions
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 69.9% of shares outstanding.
Largest holders
By investor type
Reported short interest has fallen from 2.00% to 1.82% of float over the last 6 biweekly reports (31 Jul 2026 to 15 Oct 2026).
Recent institutional activity
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Nuveen Asset Management LLC | Insurance Company | 2026/Q3 | +24,505 | 0.0% |
| HongShan Capital Advisors Limited | VC/PE Fund | 2026/Q3 | +3,750,299 | 3.5% |
| Octagon Capital Advisors LP | Hedge Fund | 2026/Q3 | +954,416 | 0.9% |
| BlackRock | Mutual Fund | 2026/Q3 | +235,313 | 0.9% |
| Geode Capital Management, LLC | Mutual Fund | 2026/Q3 | +101,536 | 0.5% |
| Vanguard Portfolio Management, LLC | Mutual Fund | 2026/Q3 | +54,139 | 0.1% |
| Northern Trust Global Investments | Mutual Fund | 2026/Q3 | +35,696 | 0.2% |
| Goldman Sachs Asset Management, L.P. | Mutual Fund | 2026/Q3 | +32,868 | 0.1% |
| Morgan Stanley | Public Company | 2026/Q3 | +31,255 | 0.0% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +29,076 | 0.2% |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Mutual Fund | 2026/Q3 | +24,505 | 0.0% |
| BNY Mellon Asset Management | Mutual Fund | 2026/Q3 | +19,606 | 0.1% |
| Charles Schwab Investment Management | Mutual Fund | 2026/Q3 | +19,048 | 0.2% |
| Millennium Management LLC | Hedge Fund | 2026/Q3 | +18,488 | 0.0% |
| T. Rowe Price Group, Inc. | Mutual Fund | 2026/Q3 | +13,747 | 0.0% |
Institutional buy/sell activity by reporting period, largest moves first.
Insider transactions
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 17 Jun 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -11,000 | $6.35 | 700,000 |
| 10 Jun 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -2,800 | $6.17 | 700,000 |
| 9 Jun 2026 | Dan Weng | Independent Director | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | David M. Epstein | Former Independent Director | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | Ping Zhang | Chairperson | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | Renate Parry | Independent Director | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | Gordon Carmichael | Independent Director | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | Rodney Nussbaum | Independent Director | Other Derivative Acquisition | +40,000 | $5.95 | 40,000 |
| 9 Jun 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -20,918 | $6.21 | 700,000 |
| 7 Jun 2026 | Ying Luo | Chief Executive Officer | Other Derivative Acquisition | +120,000 | $6.05 | 120,000 |
| 7 Jun 2026 | Joshua Bergmann | General Counsel | Other Derivative Acquisition | +50,000 | $6.05 | 50,000 |
| 4 Jun 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -34,976 | $6.40 | 700,000 |
| 25 May 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -7,500 | $6.10 | 700,000 |
| 20 May 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -22,220 | $6.15 | 700,000 |
| 18 May 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -9,320 | $6.62 | 700,000 |
| 14 May 2026 | Weiguo Ye | Chief Operating Officer | Derivative Exercise and Sale | -28,680 | $6.91 | 700,000 |
| 13 May 2026 | Ping Zhang | Chairperson | Derivative Sale to Issuer | -250,000 | – | – |
| 12 May 2026 | Weiguo Ye | Chief Operating Officer | Intent to Sell (Form 144) | -300,000 | $7.07 | – |
| 5 May 2026 | Ying Luo | Chief Executive Officer | Automatic Disposition | -10,315 | $8.04 | 2,565,226 |
| 3 May 2026 | Thomas Eastling | Chief Financial Officer | Other Derivative Acquisition | +408,757 | $5.98 | 33,271 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
Short interest, by report
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Oct 2026 | 1,927,774 | 1.8% | 16.3 |
| 30 Sep 2026 | 1,918,512 | 1.8% | 6.9 |
| 15 Sep 2026 | 1,730,215 | 1.6% | 19.2 |
| 31 Aug 2026 | 1,709,352 | 1.6% | 34.4 |
| 14 Aug 2026 | 1,745,865 | 1.6% | 31.1 |
| 31 Jul 2026 | 1,823,720 | 2.0% | 37.4 |
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