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Structure Therapeutics GPCR

US equityMarket cap rank #2795Biotechnology
$27.59 −$0.08 (-0.29%)
Pre-market · Oct 6, 4:20 am ET · After hours $27.71 +0.43%
Open$28.10
Prev close$27.67
Day range$26.41 – $28.21
Volume1.87M
Market cap$1.97B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership102.5%-1.77 pts vs. prior quarter
Institutions holding248-4 vs. prior quarter
Insider trades (recent)28 buys / 22 sellsNet buying
Short interest9.26% of floatDays to cover 5.2 · as of 15 Sep 2026
Short-sale volume share10.0%5-day average of daily volume

Short-sale volume as % of daily volume

4%9%13%18%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$10.60M (6 inflow days, 14 outflow days).

The five largest holders on file together own 48.3% of shares outstanding.

Largest holders

  • FMR10.90%
  • Deep Track Capital, LP10.59%
  • Wellington Management Group10.35%
  • Avoro Capital Advisors LLC9.19%
  • Janus Henderson Group plc7.30%
  • BVF Partners L.P.4.72%
  • Morgan Stanley3.84%
  • OrbiMed Advisors LLC3.10%

By investor type

  • Mutual Fund49.12%
  • Hedge Fund27.66%
  • VC/PE Fund18.20%
  • Public Company5.13%
  • Individual/Insider2.44%
  • Private Company1.02%
  • Government Pension Fund0.61%
  • Sovereign Wealth Fund0.60%

Reported short interest has risen from 8.62% to 9.26% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 6,605,011 9.3% 5.2
31 Aug 2026 5,854,907 8.2% 7.9
14 Aug 2026 6,079,970 8.5% 10.4
31 Jul 2026 6,049,938 8.5% 11.5
15 Jul 2026 6,206,238 8.7% 8.8
30 Jun 2026 6,127,886 8.6% 6.3

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