Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$1.27M (7 inflow days, 13 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 38.3% of shares outstanding.
Reported short interest has risen from 22.06% to 22.58% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| T. Rowe Price Group, Inc. | Mutual Fund | 2026/Q3 | +2,140,983 | 10.4% |
| BlackRock | Mutual Fund | 2026/Q3 | +1,205,403 | 8.0% |
| Vestal Point Capital, LP | Hedge Fund | 2026/Q3 | +996,535 | 5.4% |
| Woodline Partners LP | Hedge Fund | 2026/Q3 | +888,388 | 1.1% |
| Opaleye Management Inc. | Hedge Fund | 2026/Q3 | +745,000 | 0.9% |
| First Trust Advisors L.P. | Mutual Fund | 2026/Q3 | +647,796 | 0.8% |
| Boone Capital Management LLC | Hedge Fund | 2026/Q3 | +615,287 | 0.7% |
| Nextech Invest Ltd. | VC/PE Fund | 2026/Q3 | +456,916 | 0.9% |
| Vanguard Capital Management, LLC | Mutual Fund | 2026/Q3 | +411,104 | 4.6% |
| Janus Henderson Group plc | Mutual Fund | 2026/Q3 | +386,568 | 1.3% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +377,436 | 4.4% |
| Kennedy Capital Management LLC | Mutual Fund | 2026/Q3 | +373,552 | 0.5% |
| Columbia Management Investment Advisers, LLC | Mutual Fund | 2026/Q3 | +347,338 | 0.4% |
| Geode Capital Management, LLC | Mutual Fund | 2026/Q3 | +323,301 | 2.2% |
| Duquesne Family Office LLC | Family Office/Trust | 2026/Q3 | +297,600 | 0.3% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 15 Jul 2026 | Markus Warmuth | Chief Executive Officer | Open Market Disposition | -9,500 | $23.18 | 399,038 |
| 14 Jul 2026 | Jennifer Champoux | Chief People & Operations Officer | Derivative Exercise and Sale | -4,351 | $23.38 | 4,871 |
| 5 Jul 2026 | Sharon Townson | Chief Technology Officer | Derivative Exercise and Sale | -6,000 | $24.13 | 5,845 |
| 30 Jun 2026 | New Enterprise Associates, Inc. | Other Acquisition | +15,000 | – | 6,692,298 | |
| 30 Jun 2026 | New Enterprise Associates, Inc. | Other Disposition | -1,015,000 | – | 6,692,298 | |
| 29 Jun 2026 | Filip Janku | Chief Medical Officer | Derivative Exercise and Sale | -5,407 | $24.50 | 2,612 |
| 28 Jun 2026 | Anthony Manning | Director | Derivative Exercise and Sale | -10,000 | $23.11 | – |
| 28 Jun 2026 | Filip Janku | Chief Medical Officer | Derivative Exercise and Sale | -6,000 | $22.95 | 1,992 |
| 23 Jun 2026 | Filip Janku | Chief Medical Officer | Intent to Sell (Form 144) | -30,000 | $20.71 | – |
| 23 Jun 2026 | Filip Janku | Chief Medical Officer | Derivative Exercise and Sale | -36,000 | $21.42 | 1,992 |
| 22 Jun 2026 | Filip Janku | Chief Medical Officer | Automatic Disposition | -5,845 | $20.22 | 1,992 |
| 22 Jun 2026 | Sharon Townson | Chief Technology Officer | Derivative Exercise and Sale | -3,000 | $20.00 | 5,845 |
| 22 Jun 2026 | Jennifer Champoux | Chief People & Operations Officer | Derivative Exercise and Sale | -2,175 | $20.00 | 4,871 |
| 16 Jun 2026 | Sharon Townson | Chief Technology Officer | Derivative Exercise and Sale | -3,000 | $19.00 | 5,845 |
| 16 Jun 2026 | Jennifer Champoux | Chief People & Operations Officer | Derivative Exercise and Sale | -2,176 | $19.00 | 4,871 |
| 10 Jun 2026 | Christine Siu | Independent Director | Other Derivative Acquisition | +25,800 | $17.10 | 25,800 |
| 10 Jun 2026 | Andrew Schiff | Independent Chairperson | Other Derivative Acquisition | +25,800 | $17.10 | 25,800 |
| 10 Jun 2026 | Anthony Manning | Director | Other Derivative Acquisition | +25,800 | $17.10 | 25,800 |
| 10 Jun 2026 | Jan Skvarka | Independent Director | Other Derivative Acquisition | +25,800 | $17.10 | 25,800 |
| 10 Jun 2026 | Kimberly Blackwell | Independent Director & Member of Scientific Advisory Board | Other Derivative Acquisition | +25,800 | $17.10 | 25,800 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 19,265,990 | 22.6% | 17.1 |
| 31 Aug 2026 | 18,075,786 | 21.2% | 16.6 |
| 14 Aug 2026 | 17,457,317 | 20.5% | 14.0 |
| 31 Jul 2026 | 16,458,543 | 19.5% | 10.6 |
| 15 Jul 2026 | 17,195,471 | 20.4% | 13.1 |
| 30 Jun 2026 | 18,634,735 | 22.1% | 8.5 |
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