Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$1.89M (7 inflow days, 13 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 35.6% of shares outstanding.
Reported short interest has fallen from 9.14% to 8.37% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Soleus Capital Management, L.P. | Hedge Fund | 2026/Q3 | +2,657,572 | 5.3% |
| Nuveen Asset Management LLC | Insurance Company | 2026/Q3 | +101,383 | 0.2% |
| Point72 Asset Management, L.P. | Hedge Fund | 2026/Q3 | +1,508,518 | 2.3% |
| Perceptive Advisors LLC | VC/PE Fund | 2026/Q3 | +1,172,423 | 3.7% |
| BlackRock | Mutual Fund | 2026/Q3 | +550,445 | 7.3% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +376,504 | 2.6% |
| Pinnacle Associates, Ltd. | Mutual Fund | 2026/Q3 | +328,369 | 2.3% |
| Millennium Management LLC | Hedge Fund | 2026/Q3 | +326,770 | 2.7% |
| Assenagon Asset Management S.A. | Mutual Fund | 2026/Q3 | +310,035 | 1.4% |
| Walleye Capital LLC | Hedge Fund | 2026/Q3 | +253,817 | 0.4% |
| Geode Capital Management, LLC | Mutual Fund | 2026/Q3 | +227,056 | 2.4% |
| Wellington Management Group | Mutual Fund | 2026/Q3 | +169,934 | 0.3% |
| KPV Capital Advisors, LP | Hedge Fund | 2026/Q3 | +150,000 | 0.2% |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Mutual Fund | 2026/Q3 | +122,012 | 0.3% |
| The Goldman Sachs Group, Inc. | Public Company | 2026/Q3 | +114,521 | 1.4% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 1 Sep 2026 | David Moatazedi | Chief Executive Officer | Open Market Disposition | -105,108 | $9.04 | 361 |
| 19 Mar 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Automatic Disposition | -3,119 | $4.75 | 272,662 |
| 19 Mar 2026 | David Moatazedi | Chief Executive Officer | Automatic Disposition | -13,669 | $4.75 | 105,469 |
| 16 Mar 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Automatic Disposition | -21,192 | $4.89 | 275,781 |
| 16 Mar 2026 | David Moatazedi | Chief Executive Officer | Automatic Disposition | -49,231 | $4.89 | 119,138 |
| 16 Mar 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Derivative Exercise and Sale | -8,804 | $4.89 | 275,781 |
| 16 Mar 2026 | David Moatazedi | Chief Executive Officer | Derivative Exercise and Sale | -67,489 | $4.89 | 119,138 |
| 16 Feb 2026 | David Gill | Independent Director | Other Acquisition | +45,559 | – | 52,923 |
| 16 Feb 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Other Acquisition | +94,913 | – | 160,705 |
| 16 Feb 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Other Derivative Acquisition | +94,913 | – | 94,913 |
| 16 Feb 2026 | Rui Avelar | Chief Medical Officer and Head of Research & Development | Other Derivative Acquisition | +138,649 | $4.39 | 138,649 |
| 16 Feb 2026 | Albert White | Independent Director | Other Acquisition | +45,559 | – | 64,430 |
| 16 Feb 2026 | Vikram Malik | Chairperson | Other Acquisition | +45,559 | – | 52,923 |
| 16 Feb 2026 | Karah Parschauer | Independent Director | Other Acquisition | +45,559 | – | 52,923 |
| 16 Feb 2026 | David Moatazedi | Chief Executive Officer | Other Acquisition | +313,212 | – | 523,081 |
| 16 Feb 2026 | David Moatazedi | Chief Executive Officer | Other Derivative Acquisition | +457,541 | $4.39 | 457,541 |
| 16 Feb 2026 | David Moatazedi | Chief Executive Officer | Other Derivative Acquisition | +626,424 | – | 626,424 |
| 16 Feb 2026 | Brady Stewart | Independent Director | Other Acquisition | +45,559 | – | 52,923 |
| 16 Feb 2026 | Tatjana Mitchell | Chief Financial Officer | Other Acquisition | +121,489 | – | 226,092 |
| 16 Feb 2026 | Tatjana Mitchell | Chief Financial Officer | Other Derivative Acquisition | +121,489 | – | 121,489 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 5,530,759 | 8.4% | 6.6 |
| 31 Aug 2026 | 5,368,957 | 8.1% | 5.2 |
| 14 Aug 2026 | 5,853,655 | 8.9% | 4.4 |
| 31 Jul 2026 | 5,568,442 | 8.5% | 8.7 |
| 15 Jul 2026 | 5,905,990 | 9.0% | 7.3 |
| 30 Jun 2026 | 6,018,141 | 9.1% | 7.3 |
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