Design Therapeutics DSGN

Pratik Shah, Ph.D., has served as our President, Chief Executive Officer and Chairperson since August 2023 and before that served as our Executive Chairperson and a member of our Board of Directors since December 2017. Dr. Shah also serves as the Chairperson of the board of directors for ARS Pharmaceuticals, Inc. and has been a member of its board of directors since April 2016. He has also served as President of Marlinspike Group, LLC since August 2018 and of Marlinspike Group, Inc. from June 2015 to October 2020. Dr. Shah served as the Chairman of the board of directors of Synthorx, Inc. from October 2018 until its acquisition by Sanofi S.A. in January 2020. Dr. Shah also served as the President and Chief Executive Officer and Chairman of the board of directors of Auspex Pharmaceuticals, Inc. from October 2013 until its acquisition by Teva Pharmaceuticals Industries Ltd. in May 2015. From 2004 to 2014 he was a partner at Thomas, McNerney & Partners. Dr. Shah holds a B.S. in Biological Sciences from the University of California at Irvine and a Ph.D. in Biochemistry and Molecular Biology and an M.B.A. in Finance, both from the University of Chicago.

Chris M. Storgard, M.D., has served as our Chief Medical Officer since April 2025. Dr. Storgard served as Chief Medical Officer of ADARx Pharmaceuticals, Inc. from April 2024 to March 2025. From December 2019 to March 2024, Dr. Storgard served as Chief Medical Officer of Heron Therapeutics, Inc. after serving as its Senior Vice President, Clinical Development from November 2018 to December 2019. Dr. Storgard also served as Chief Medical Officer of Fate Therapeutics, Inc from May 2016 to November 2018. Dr. Storgard holds an M.D. and BSc from the University of Saskatchewan and is board-certified in Rheumatology and Internal Medicine.

Sean Jeffries, Ph.D., has served as our Chief Operating Officer since January 2021 and as our Chief Business Officer from May 2019 to January 2021. Dr. Jeffries served as a principal of Marlinspike Group, Inc. from February 2018 to December 2018 and Marlinspike Group, LLC from January 2019 to February 2020. From April 2014 to January 2018, Dr. Jeffries worked as a Management Consultant at The Boston Consulting Group leading biopharma R&D strategy projects as a core member of the Healthcare and Private Equity groups. Dr. Jeffries holds a B.A. in Computer Science from the College of Wooster and a Ph.D. in Physiology, Development and Neuroscience from the University of Cambridge.

Rodney Lappe, Ph.D., has served as a member of our Board of Directors since July 2019 and as a consultant to the Company since November 2023. From June 2012 to February 2019, Dr. Lappe served as Executive Chairman, Chairman and a member of the board of directors for Mirati Therapeutics, Inc. From January 2012 to April 2019, Dr. Lappe served as the Senior Vice President of Tavistock Life Sciences Co., a private investment firm. From January 2004 to December 2011, Dr. Lappe was Group Senior Vice President, Pfizer Worldwide Research and Development and Chief Scientific Officer for CovX Pharmaceuticals Inc. (CovX). Dr. Lappe joined Pfizer with the CovX acquisition in January 2008. From August 2000 to December 2003, Dr. Lappe served as Vice President for cardiovascular and metabolic diseases at Pharmacia Group. He was also site leader for Pharmacia in St. Louis. Prior to joining Pharmacia, he held positions of increasing responsibility with Wyeth Pharmaceuticals, Rorer Central Research, CIBA Geigy and Searle Pharmaceuticals. Dr. Lappe received his B.A. from Blackburn College and his Ph.D. in Pharmacology from Indiana University.

Justin Gover has served as a member of our Board of Directors since September 2025. Mr. Gover has served as a member of the board of directors of Xenon Pharmaceuticals Inc. since August 2023 and Compass Pathways plc since July 2025. From 1999 to May 2021, Mr. Gover served as the founding Chief Executive Officer and as a director of GW Pharmaceuticals plc until its sale to Jazz Pharmaceuticals plc. From 2018 to 2021, Mr. Gover served on the board of directors of the Biotechnology Innovation Organization (BIO). Mr. Gover currently serves on the board of directors for Aeovian Pharmaceuticals, Inc., a private biotechnology company, Rady Children's Institute for Genomic Medicine and CURE Epilepsy where he is Board Chair. Mr. Gover holds an M.B.A. from the INSEAD business school in France and a B.Sc. (Hons) from Bristol University, UK.

Simeon George, M.D., has served as a member of our Board of Directors since February 2020 and as our Lead Independent Director since August 2023. Since September 2020, Dr. George has served as the Chief Executive Officer and Managing Partner of SR One, a transatlantic biotech venture capital firm. Dr. George previously served in various roles at S.R. One, Limited (now called GSK Equity Investments, Limited), an indirect, wholly-owned subsidiary of GlaxoSmithKline plc, from 2007 to September 2020, most recently serving as Chief Executive Officer from January 2018 to September 2020. Dr. George was formerly a consultant at Bain & Company, and an investment banker at Goldman Sachs and Merrill Lynch. Dr. George currently serves on the boards of directors of the following public companies: CRISPR Therapeutics AG since March 2015 and Nkarta, Inc. since February 2020 (and previously from February 2015 to September 2017). Dr. George previously served on the boards of directors of Arcellx, Inc. (including co-founding the company) from January 2015 to September 2017, Turning Point Therapeutics, Inc. from May 2017 through its acquisition in August 2022, Principia Biopharma Inc. from February 2011 through its acquisition in September 2020, Progyny from May 2012 until October 2019, HTG Molecular Diagnostics, Inc., from June 2011 until October 2015, and Genocea Biosciences, Inc., from February 2009 to December 2014. Dr. George received his B.A. in Neuroscience from Johns Hopkins University, where he graduated Phi Beta Kappa. He received his M.D. from the University of Pennsylvania's School of Medicine and his M.B.A. (Mayer Scholar) from the Wharton School of the University of Pennsylvania.

John Schmid has served as a member of our Board of Directors since November 2020. Mr. Schmid has served as a member of the boards of directors of AnaptysBio, Inc. since June 2015, Bright Peak Therapeutics since March 2025, Helix Acquisition Corp III since January 2026, and First Tracks Biotherapeutics, Inc. since April 2026. In addition, Mr. Schmid serves as chairman of the board of directors of Speak, Inc., a speakers bureau, which he helped found in 1989. Mr. Schmid also served as a member of the board of directors of Xeris Pharmaceuticals from September 2017 to June 2025, Poseida Therapeutics Inc. from July 2018 to January 2025, Blacksmith Medicines (formerly known as Forge Therapeutics, Inc.) from May 2017 to April 2024, Neos Therapeutics from June 2015 to March 2021, Helix Acquisition Corporation from October 2020 to April 2022 and Helix Acquisition Corporation II from February 2024 to August 2025. From September 2013 to June 2015, Mr. Schmid served as Chief Financial Officer of Auspex Pharmaceuticals, Inc. until its sale to Teva Pharmaceutical Industries Ltd. From June 2004 to September 2013, Mr. Schmid co-founded Trius Therapeutics where he served as the Chief Financial Officer until its merger with Cubist Pharmaceuticals, Inc. From 1998 to 2003, Mr. Schmid served as the Chief Financial Officer of GeneFormatics, Inc. From 1995 to 1998, Mr. Schmid served as the Chief Financial Officer of Endonetics Inc. Mr. Schmid received a B.A. in Economics from Wesleyan University and an M.B.A. from the University of San Diego.

Heather Berger, Ph.D., has served as a member of our Board of Directors since June 2021. Dr. Berger has served as a Venture Partner at Forge Life Science Partners since January 2026. Dr. Berger previously served as Chief Business Officer of Iolyx Therapeutics from May 2023 to January 2026. From September 2020 to December 2022, Dr. Berger served as a Principal at SR One. Dr. Berger was previously a Principal at S.R. One, Limited (now called GSK Equity Investments, Limited), an indirect, wholly-owned subsidiary of GlaxoSmithKline plc, from April 2019 to September 2020. From January 2017 to December 2018, Dr. Berger was a Principal at Sofinnova Ventures focusing on biopharmaceutical investments. Dr. Berger served as a Senior Vice President and biotechnology sell-side analyst at Wedbush Securities from August 2014 to December 2016, preceded by a role as an associate at JMP Securities from September 2010 to June 2014. Prior to this, Dr. Berger worked in early-stage drug discovery at the Astellas Research Institute and was also an adjunct professor at the Feinberg School of Medicine at Northwestern University. Dr. Berger served as a member of the board of directors of Entasis Therapeutics Holdings Inc. from August 2017 to July 2022 and a member of the board of directors of Second Genome from November 2020 to December 2022. Dr. Berger received her Ph.D. in Chemistry from Northwestern University, an M.S. in Organic Chemistry from the Weizmann Institute of Science and her B.S. from Tufts University.

David Shapiro, M.D. has served as a member of our Board of Directors since March 2026. Dr. Shapiro previously served on the board of directors of Galecto Inc., now Damora Therapeutics, Inc., from May 2020 to November 2025 and Organovo Holdings, Inc. from December 2018 until July 2020. From 1998 to April 2024, Dr. Shapiro served as the President and Chief Executive Officer of Integrated Quality Resources, a biotechnology and pharmaceutical development consulting company. Dr. Shapiro served as Chief Medical Officer and head of R&D at Intercept Pharmaceuticals, Inc., a biopharmaceutical company, from April 2007 to May 2019. Earlier in his career, Dr. Shapiro was Chief Medical Officer, EVP Medical Affairs at Idun Pharmaceuticals, Inc., a biotechnology company which was acquired by Pfizer in 2005. Dr. Shapiro also served as President of the Scripps Medical Research Center at Scripps Clinic from 1995 to 1997 and has held senior appointments at several biotechnology companies. Prior to joining the biotechnology sector, he led Merck & Co.'s hypertension clinical research program. Dr. Shapiro has served on the board of directors of several private companies and currently serves on the board of directors of Precision Biosciences, Inc. Dr. Shapiro holds an M.D. from Dundee University and Medical School and trained in general and respiratory medicine at the Oxford University Teaching Hospitals and the University of Vermont. He is a fellow of the Royal College of Physicians of London (FRCP) and is an FFPM and FAASLD.

On March 31, 2026, the Board appointed David Shapiro, M.D., to the Board as a Class III director, effective immediately.

Ms. Burgess, age 52, has served as Senior Vice President, Finance at Otonomy, Inc. (Otonomy), a biopharmaceutical company, since April 2021, and before that served as Otonomy's Vice President, Finance and Administration from January 2014 to April 2021. Prior to Otonomy, Ms. Burgess served as the Corporate Controller for Apricus Biosciences, Inc. from March 2012 to October 2013. She has also previously served as an independent consultant to several other biopharmaceutical companies including Cypress Biosciences, Inc. and Ocera Therapeutics, Inc. (now, Mallinckrodt Pharmaceuticals), and as an auditor at KPMG, LLP. Ms. Burgess has more than 25 years of experience in financial reporting, technical accounting, debt and equity financings, and financial planning and management for public and private companies and is a licensed Certified Public Accountant (California active). Ms. Burgess received her B.A. in Business Economics from the University of California, Santa Barbara and her M.S. in Business Administration from San Diego State University.