Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: +$537.1K (8 inflow days, 12 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 43.6% of shares outstanding.
Reported short interest has fallen from 9.15% to 8.73% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Sirenia Capital Management LP | Mutual Fund | 2026/Q3 | +5,453,736 | 8.7% |
| Frazier Life Sciences Management, LP | VC/PE Fund | 2026/Q3 | +1,809,854 | 2.9% |
| Trails Edge Capital Partners, LP | Hedge Fund | 2026/Q3 | +1,149,269 | 3.2% |
| Logos Global Management, L.P. | Hedge Fund | 2026/Q3 | +1,050,000 | 4.8% |
| Caption Management, LLC | Hedge Fund | 2026/Q3 | +1,031,390 | 1.8% |
| Driehaus Capital Management LLC | Mutual Fund | 2026/Q3 | +916,128 | 4.3% |
| Sofinnova Investments, Inc. | VC/PE Fund | 2026/Q3 | +865,135 | 1.4% |
| BlackRock | Mutual Fund | 2026/Q3 | +526,260 | 4.3% |
| Artal Group S.A. | VC/PE Fund | 2026/Q3 | +523,212 | 0.8% |
| Qube Research & Technologies Ltd | Mutual Fund | 2026/Q3 | +402,896 | 0.7% |
| The Goldman Sachs Group, Inc. | Public Company | 2026/Q3 | +333,053 | 0.7% |
| Jacobs Levy Equity Management Inc | Mutual Fund | 2026/Q3 | +276,212 | 0.9% |
| Geode Capital Management, LLC | Mutual Fund | 2026/Q3 | +265,899 | 1.5% |
| Dimensional Fund Advisors | Mutual Fund | 2026/Q3 | +262,903 | 1.1% |
| Vanguard Capital Management, LLC | Mutual Fund | 2026/Q3 | +255,716 | 2.9% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 8 Jun 2026 | John Schmid | Independent Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 8 Jun 2026 | Justin Gover | Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 8 Jun 2026 | David Shapiro | Independent Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 8 Jun 2026 | Rodney Lappe | Independent Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 8 Jun 2026 | Simeon George | Lead Independent Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 8 Jun 2026 | Heather Berger | Independent Director | Other Derivative Acquisition | +30,000 | $10.55 | 30,000 |
| 30 Mar 2026 | David Shapiro | Independent Director | Other Derivative Acquisition | +67,500 | $10.64 | 7,500 |
| 1 Jan 2026 | Pratik Shah | Co-Founder, President, CEO, Principal Financial Officer & Executive Chairperson | Other Derivative Acquisition | +750,000 | $9.10 | 750,000 |
| 1 Jan 2026 | Justin Gover | Director | Other Derivative Acquisition | +45,000 | $9.10 | 45,000 |
| 1 Jan 2026 | Chris Storgard | Chief Medical Officer | Other Derivative Acquisition | +250,000 | $9.10 | 250,000 |
| 1 Jan 2026 | Sean Jeffries | Chief Operating Officer | Other Derivative Acquisition | +375,000 | $9.10 | 375,000 |
| 1 Jan 2026 | Julie Burgess | Chief Accounting Officer | Other Derivative Acquisition | +150,000 | $9.10 | 150,000 |
| 8 Dec 2025 | Pratik Shah | Co-Founder, President, CEO, Principal Financial Officer & Executive Chairperson | Other Derivative Acquisition | +1,050,000 | $2.48 | 525,000 |
| 17 Nov 2025 | Logos Global Management, L.P. | Intent to Sell (Form 144) | -120,000 | $7.43 | – | |
| 13 Nov 2025 | Logos Global Management, L.P. | Intent to Sell (Form 144) | -620,000 | $7.06 | – | |
| 6 Nov 2025 | Logos Global Management, L.P. | Intent to Sell (Form 144) | -415,000 | $6.87 | – | |
| 8 Sep 2025 | Justin Gover | Director | Other Derivative Acquisition | +45,833 | $6.64 | 15,833 |
| 12 Aug 2025 | Logos Global Management, L.P. | Open Market Disposition | -562,627 | $5.25 | 3,655,000 | |
| 9 Jun 2025 | John Schmid | Independent Director | Other Derivative Acquisition | +19,000 | $4.01 | 19,000 |
| 9 Jun 2025 | Rodney Lappe | Independent Director | Other Derivative Acquisition | +19,000 | $4.01 | 19,000 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 5,461,508 | 8.7% | 7.3 |
| 31 Aug 2026 | 5,542,463 | 8.9% | 9.0 |
| 14 Aug 2026 | 5,925,557 | 9.5% | 15.2 |
| 31 Jul 2026 | 5,952,223 | 9.5% | 12.0 |
| 15 Jul 2026 | 5,669,571 | 9.1% | 6.4 |
| 30 Jun 2026 | 5,715,760 | 9.2% | 5.2 |
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