Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$93.6K (9 inflow days, 11 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 31.8% of shares outstanding.
Reported short interest has risen from 6.70% to 6.80% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Forbion Capital Partners B.V. | VC/PE Fund | 2026/Q3 | +1,195,066 | 5.1% |
| TCG Crossover Management, LLC | VC/PE Fund | 2026/Q3 | +9,533,333 | 9.2% |
| Caligan Partners, LP | Hedge Fund | 2026/Q3 | +4,068,384 | 4.1% |
| OrbiMed Advisors LLC | VC/PE Fund | 2026/Q3 | +3,333,333 | 3.2% |
| Montanova Capital, LLC | Hedge Fund | 2026/Q3 | +2,833,333 | 6.9% |
| RA Capital Management, L.P. | VC/PE Fund | 2026/Q3 | +2,500,000 | 2.4% |
| Janus Henderson Group plc | Mutual Fund | 2026/Q3 | +2,500,000 | 2.4% |
| Vanguard Capital Management, LLC | Mutual Fund | 2026/Q3 | +2,096,558 | 4.6% |
| Balyasny Asset Management L.P. | Hedge Fund | 2026/Q3 | +1,796,965 | 2.3% |
| Redmile Group, LLC | Hedge Fund | 2026/Q3 | +1,666,667 | 1.6% |
| EcoR1 Capital, LLC | Hedge Fund | 2026/Q3 | +1,666,667 | 1.6% |
| Trails Edge Capital Partners, LP | Hedge Fund | 2026/Q3 | +1,443,333 | 1.4% |
| Foresite Capital Management, LLC | VC/PE Fund | 2026/Q3 | +1,333,334 | 1.3% |
| Woodline Partners LP | Hedge Fund | 2026/Q3 | +1,210,183 | 1.2% |
| Bellevue Asset Management AG | Mutual Fund | 2026/Q3 | +1,166,667 | 1.1% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 31 Aug 2026 | Julie Person | Chief Human Resources Officer | Other Acquisition | +107,611 | – | 107,611 |
| 31 Aug 2026 | Julie Person | Chief Human Resources Officer | Other Derivative Acquisition | +212,389 | $7.43 | 212,389 |
| 31 Aug 2026 | Erica Kratz | Chief Regulatory & Quality Officer | Other Acquisition | +100,885 | – | 100,885 |
| 31 Aug 2026 | Erica Kratz | Chief Regulatory & Quality Officer | Other Derivative Acquisition | +199,115 | $7.43 | 199,115 |
| 31 Aug 2026 | J. Hopkins | Chief Medical Officer & President of Research and Development | Other Acquisition | +58,850 | – | 60,050 |
| 31 Aug 2026 | J. Hopkins | Chief Medical Officer & President of Research and Development | Other Derivative Acquisition | +116,150 | $7.43 | 116,150 |
| 31 Aug 2026 | Amy Elazzouzi | Interim Principal Financial Officer & Interim Principal Accounting Officer | Other Acquisition | +23,540 | – | 143,600 |
| 31 Aug 2026 | Amy Elazzouzi | Interim Principal Financial Officer & Interim Principal Accounting Officer | Other Derivative Acquisition | +46,460 | $7.43 | 46,460 |
| 6 Jul 2026 | Jeremy Bender | Independent Director | Other Acquisition | +30,000 | – | 30,000 |
| 6 Jul 2026 | Jeremy Bender | Independent Director | Other Derivative Acquisition | +60,000 | $7.03 | 60,000 |
| 30 Jun 2026 | Conor Kilroy | General Counsel | Other Acquisition | +14,858 | – | 193,053 |
| 15 Jun 2026 | Anthony Gibney | Chief Financial & Business Officer | Open Market Disposition | -12,824 | $6.42 | 81,609 |
| 10 Jun 2026 | Sapna Srivastava | Independent Director | Other Acquisition | +15,000 | – | 15,000 |
| 10 Jun 2026 | Sapna Srivastava | Independent Director | Other Derivative Acquisition | +30,000 | $6.21 | 30,000 |
| 10 Jun 2026 | Antony Mattessich | Independent Director | Other Acquisition | +15,000 | – | 15,000 |
| 10 Jun 2026 | Antony Mattessich | Independent Director | Other Derivative Acquisition | +30,000 | $6.21 | 30,000 |
| 10 Jun 2026 | David Johnson | Independent Chairperson | Other Acquisition | +15,000 | – | 15,000 |
| 10 Jun 2026 | David Johnson | Independent Chairperson | Other Derivative Acquisition | +30,000 | $6.21 | 30,000 |
| 10 Jun 2026 | Teresa Marie Bitetti | Director | Other Acquisition | +15,000 | – | 29,000 |
| 10 Jun 2026 | Teresa Marie Bitetti | Director | Other Derivative Acquisition | +30,000 | $6.21 | 30,000 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 7,049,973 | 6.8% | 11.7 |
| 31 Aug 2026 | 6,203,498 | 6.0% | 6.4 |
| 14 Aug 2026 | 6,158,945 | 5.9% | 9.9 |
| 31 Jul 2026 | 6,358,049 | 6.1% | 18.5 |
| 15 Jul 2026 | 5,608,945 | 5.4% | 8.1 |
| 30 Jun 2026 | 6,932,229 | 6.7% | 9.3 |
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