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Zymeworks ZYME

US equityMarket cap rank #2821Biotechnology
$26.21 +$1.06 (+4.21%)
Pre-market · Oct 6, 4:10 am ET · After hours $26.21 0.00%
Open$25.37
Prev close$25.15
Day range$25.28 – $26.51
Volume1.04M
Market cap$1.88B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership98.2%-0.09 pts vs. prior quarter
Institutions holding252-2 vs. prior quarter
Insider trades (recent)32 buys / 3 sellsNet buying
Short interest6.96% of floatDays to cover 8.0 · as of 15 Sep 2026
Short-sale volume share11.8%5-day average of daily volume

Short-sale volume as % of daily volume

8%13%18%23%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$2.60M (3 inflow days, 17 outflow days).

The five largest holders on file together own 59.3% of shares outstanding.

Largest holders

  • EcoR1 Capital, LLC32.37%
  • Rubric Capital Management LP9.86%
  • BlackRock5.99%
  • Perceptive Advisors LLC5.89%
  • BVF Partners L.P.5.14%
  • Morgan Stanley3.03%
  • Vanguard Capital Management, LLC2.31%
  • BNPP Asset Management Holding2.30%

By investor type

  • Hedge Fund52.96%
  • Mutual Fund31.90%
  • VC/PE Fund7.51%
  • Public Company4.83%
  • Individual/Insider1.32%
  • Private Company0.52%
  • Government Pension Fund0.43%
  • Sovereign Wealth Fund0.00%

Reported short interest has risen from 5.93% to 6.96% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 4,939,072 7.0% 8.0
31 Aug 2026 4,724,831 6.7% 5.7
14 Aug 2026 4,538,353 6.4% 8.5
31 Jul 2026 4,106,590 5.6% 10.9
15 Jul 2026 4,102,257 5.6% 7.6
30 Jun 2026 4,364,318 5.9% 6.2

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