BeStock  
Stocks › SEPN

Septerna SEPN

US equityMarket cap rank #2871
$37.87 +$0.16 (+0.42%)
Pre-market · Oct 6, 5:40 am ET · After hours $37.87 0.00%
Open$37.83
Prev close$37.71
Day range$36.82 – $38.52
Volume266.7K
Market cap$1.77B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership99.0%-5.95 pts vs. prior quarter
Institutions holding193+1 vs. prior quarter
Insider trades (recent)32 buys / 18 sellsNet buying
Short interest6.20% of floatDays to cover 9.5 · as of 15 Sep 2026
Short-sale volume share27.3%5-day average of daily volume

Short-sale volume as % of daily volume

13%21%29%37%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$4.81M (5 inflow days, 15 outflow days).

The five largest holders on file together own 54.2% of shares outstanding.

Largest holders

  • Third Rock Ventures, LLC22.02%
  • RA Capital Management, L.P.11.79%
  • Driehaus Capital Management LLC9.50%
  • Samsara BioCapital LLC6.75%
  • BlackRock4.14%
  • Artal Group S.A.4.07%
  • The Goldman Sachs Group, Inc.3.68%
  • Vanguard Capital Management, LLC2.97%

By investor type

  • VC/PE Fund47.48%
  • Mutual Fund37.64%
  • Hedge Fund9.04%
  • Public Company4.30%
  • Individual/Insider2.86%
  • Private Company0.35%
  • Government Pension Fund0.17%
  • Sovereign Wealth Fund0.04%

Reported short interest has fallen from 7.00% to 6.20% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 2,894,002 6.2% 9.5
31 Aug 2026 2,718,332 5.8% 7.7
14 Aug 2026 2,874,690 6.2% 5.1
31 Jul 2026 3,507,965 7.8% 14.2
15 Jul 2026 3,350,617 7.4% 5.7
30 Jun 2026 3,154,131 7.0% 5.3

Discussion

No comments yet — be the first to weigh in on SEPN.

Leave a comment

Scroll to Top