BeStock  

Opko Health OPK

US equityMarket cap rank #3217Diagnostics & Research
$1.39 −$0.07 (-4.79%)
Pre-market · Oct 8, 9:10 am ET · After hours $1.39 -0.02%
Open$1.42
Prev close$1.46
Day range$1.38 – $1.43
Volume2.22M
Market cap$1.04B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership34.8%+0.31 pts vs. prior quarter
Institutions holding260-1 vs. prior quarter
Insider trades (recent)45 buys / 3 sellsNet buying
Short interest4.82% of floatDays to cover 10.6 · as of 15 Sep 2026
Short-sale volume share17.9%5-day average of daily volume

Short-sale volume as % of daily volume

14%18%22%27%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$1.77M (7 inflow days, 13 outflow days).

Net flow by order size, last 20 sessions

−$2.8MSuper+$1.0MBig+$247.2KMid−$2.3MSmall

Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.

The five largest holders on file together own 50.6% of shares outstanding.

Largest holders

  • Phillip Frost29.45%
  • Rubric Capital Management LP6.40%
  • Gary Nabel5.40%
  • BlackRock4.95%
  • Jane Hsiao4.44%
  • Frost Group, LLC4.04%
  • Elias Zerhouni2.74%
  • Eaz Zeraz Trust2.65%

By investor type

  • Individual/Insider43.22%
  • Mutual Fund18.05%
  • Hedge Fund8.28%
  • VC/PE Fund4.04%
  • Private Company3.26%
  • Public Company0.62%
  • Family Office/Trust0.23%
  • Government Pension Fund0.22%

Reported short interest has risen from 4.32% to 4.82% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Recent institutional activity

HolderTypePeriodShare changeNew stake
Nuveen Asset Management LLC Insurance Company 2026/Q3 +814,726 0.1%
Steven Rubin Individual/Insider 2026/Q3 +165,484 0.9%
Adam Logal Individual/Insider 2026/Q3 +165,484 0.0%
Highbridge Capital Management, LLC Hedge Fund 2026/Q3 +3,593,925 0.5%
State Street Global Advisors Mutual Fund 2026/Q3 +807,693 1.4%
BlackRock Mutual Fund 2026/Q3 +746,670 5.0%
Morgan Stanley Public Company 2026/Q3 +657,829 0.2%
California State Teachers' Retirement System Government Pension Fund 2026/Q3 +547,447 0.1%
GW&K Investment Management, LLC Mutual Fund 2026/Q3 +539,109 0.1%
AQR Capital Management Hedge Fund 2026/Q3 +472,854 0.2%
Vanguard Capital Management, LLC Mutual Fund 2026/Q3 +433,984 2.4%
Algert Global LLC Hedge Fund 2026/Q3 +397,030 0.1%
Geode Capital Management, LLC Mutual Fund 2026/Q3 +279,526 1.6%
Van Eck Associates Corporation Mutual Fund 2026/Q3 +278,549 0.1%
Whitefort Capital Management, LP Hedge Fund 2026/Q3 +258,072 0.6%

Institutional buy/sell activity by reporting period, largest moves first.

Insider transactions

DateInsiderTitleTransactionSharesPriceHeld after
23 Jul 2026 Steven Rubin Executive VP of Administration & Director Sale to Issuer -53,266 $1.22 6,353,216
23 Jul 2026 Adam Logal Senior VP, CFO, Chief Accounting Officer & Treasurer Sale to Issuer -53,266 $1.22 344,646
17 Jun 2026 Roger Medel Independent Director Other Derivative Acquisition +30,000 $1.42 30,000
17 Jun 2026 Richard Pfenniger Lead Independent Director Other Derivative Acquisition +60,000 $1.42 60,000
17 Jun 2026 John Paganelli Independent Director Other Derivative Acquisition +30,000 $1.42 30,000
17 Jun 2026 Prem Lachman Independent Director Other Derivative Acquisition +30,000 $1.42 30,000
17 Jun 2026 Subbarao Uppaluri Former Chief Financial Officer Other Derivative Acquisition +80,000 $1.42 80,000
17 Jun 2026 Lin-Tsing Yu Independent Director Other Derivative Acquisition +30,000 $1.42 30,000
19 Mar 2026 John Paganelli Independent Director Open Market Acquisition +10,000 $1.14 403,515
17 Mar 2026 Subbarao Uppaluri Former Chief Financial Officer Other Derivative Acquisition +50,000 $1.17 50,000
17 Mar 2026 Subbarao Uppaluri Former Chief Financial Officer Initial Statement of Beneficial +0 – 1,158,817
17 Mar 2026 Uppaluri Investments LLC Initial Statement of Beneficial +0 – 2,000,000
20 Nov 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +580,000 $1.34 220,275,399
19 Nov 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +580,000 $1.35 249,822,576
18 Nov 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +580,000 $1.32 249,242,576
17 Nov 2025 Phillip Frost Chairperson & CEO Other Acquisition +46,700 $1.26 248,662,576
17 Nov 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +533,300 $1.29 248,662,576
30 Oct 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +150,000 $1.42 248,082,576
17 Aug 2025 Phillip Frost Chairperson & CEO Other Disposition -440,000 – 247,932,576
7 Aug 2025 Phillip Frost Chairperson & CEO Open Market Acquisition +675,000 $1.32 248,372,576

From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 35,987,629 4.8% 10.6
31 Aug 2026 34,558,372 4.6% 13.8
14 Aug 2026 33,649,355 4.5% 12.4
31 Jul 2026 32,883,700 4.4% 5.4
15 Jul 2026 33,644,789 4.5% 13.0
30 Jun 2026 32,594,765 4.3% 8.9

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