Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: +$1.59M (9 inflow days, 11 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 41.7% of shares outstanding.
Reported short interest has risen from 3.74% to 4.60% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| FMR | Mutual Fund | 2026/Q3 | +5,179,262 | 10.8% |
| SR One Capital Management, LP | VC/PE Fund | 2026/Q3 | +3,794,883 | 7.9% |
| TPG Capital, L.P. | VC/PE Fund | 2026/Q3 | +3,690,146 | 7.7% |
| Lightspeed Management Company, LLC | VC/PE Fund | 2026/Q3 | +3,608,443 | 7.5% |
| OrbiMed Advisors LLC | VC/PE Fund | 2026/Q3 | +3,001,198 | 6.3% |
| Sanofi | Public Company | 2026/Q3 | +1,991,918 | 4.2% |
| Deerfield Management Company, L.P. | Hedge Fund | 2026/Q3 | +1,046,139 | 2.2% |
| Sands Capital Alternatives, LLC | VC/PE Fund | 2026/Q3 | +875,000 | 1.8% |
| Hillhouse Capital Management, Ltd. | VC/PE Fund | 2026/Q3 | +831,656 | 1.7% |
| Vanguard Capital Management, LLC | Mutual Fund | 2026/Q3 | +821,345 | 1.7% |
| General Catalyst Group Management, LLC | VC/PE Fund | 2026/Q3 | +810,272 | 1.7% |
| Affinity Asset Advisors, LLC | Hedge Fund | 2026/Q3 | +766,346 | 1.6% |
| Adage Capital Management, L.P. | Hedge Fund | 2026/Q3 | +725,000 | 1.5% |
| Foresite Capital Management, LLC | VC/PE Fund | 2026/Q3 | +713,105 | 1.5% |
| Vivo Capital, LLC | VC/PE Fund | 2026/Q3 | +575,000 | 1.2% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 10 May 2026 | TPG Capital, L.P. | Other Acquisition | +423,111 | – | – | |
| 10 May 2026 | TPG Capital, L.P. | Other Disposition | -2,351 | $18.00 | – | |
| 10 May 2026 | TPG Capital, L.P. | Private Acquisition | +1,388,889 | $18.00 | – | |
| 10 May 2026 | TPG Capital, L.P. | Other Derivative Disposition | -423,111 | – | – | |
| 10 May 2026 | TPG Capital, L.P. | Derivative Exercise and Retained | +1,880,497 | – | – | |
| 10 May 2026 | Jeffrey Leiden | Independent Chairperson | Derivative Exercise and Sale | -17 | $18.00 | 301,842 |
| 10 May 2026 | Jeffrey Leiden | Independent Chairperson | Derivative Exercise and Retained | +31,644 | – | 301,842 |
| 10 May 2026 | Shelley Chu | Independent Director | Private Acquisition | +11,111 | $18.00 | 11,111 |
| 10 May 2026 | Gary Glick | Chief Executive Officer | Derivative Exercise and Retained | +27,386 | – | 415,973 |
| 10 May 2026 | Anthony Opipari | Derivative Exercise and Sale | -4 | $18.00 | 7,502 | |
| 10 May 2026 | Anthony Opipari | Derivative Exercise and Retained | +7,502 | – | 7,502 | |
| 10 May 2026 | SR One Capital Management, LP | Private Acquisition | +555,555 | $18.00 | 3,794,883 | |
| 10 May 2026 | SR One Capital Management, LP | Derivative Exercise and Sale | -1,780 | $18.00 | 3,794,883 | |
| 10 May 2026 | SR One Capital Management, LP | Derivative Exercise and Retained | +3,239,328 | – | 3,794,883 | |
| 10 May 2026 | Dimension Management, L.P. | Private Acquisition | +1,111,111 | $18.00 | 3,333,516 | |
| 10 May 2026 | Dimension Management, L.P. | Derivative Exercise and Retained | +1,709,543 | – | 3,333,516 | |
| 7 May 2026 | Jeffrey Leiden | Independent Chairperson | Private Acquisition | +5,000 | $20.00 | 301,842 |
| 7 May 2026 | Jason Haas | Chief Financial Officer | Open Market Acquisition | +1,000 | $20.00 | 62,908 |
| 6 May 2026 | TPG Capital, L.P. | Initial Statement of Beneficial | +0 | – | 1,880,497 | |
| 6 May 2026 | Jeffrey Leiden | Independent Chairperson | Other Derivative Acquisition | +626,220 | $18.00 | 626,220 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 2,208,686 | 4.6% | 10.8 |
| 31 Aug 2026 | 2,208,908 | 4.6% | 12.8 |
| 14 Aug 2026 | 2,249,359 | 4.7% | 18.7 |
| 31 Jul 2026 | 2,270,930 | 4.7% | 9.7 |
| 15 Jul 2026 | 1,993,860 | 4.2% | 6.5 |
| 30 Jun 2026 | 1,796,735 | 3.7% | 3.7 |
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