Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$711.2K (10 inflow days, 10 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 50.9% of shares outstanding.
Reported short interest has fallen from 22.69% to 12.58% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Chandler Robinson | Individual/Insider | 2026/Q3 | +5,457 | 2.5% |
| Nuveen Asset Management LLC | Insurance Company | 2026/Q3 | +5,980 | 0.1% |
| OrbiMed Advisors LLC | VC/PE Fund | 2026/Q3 | +157,423 | 2.3% |
| Candriam, Société En Commandite Par Actions | Mutual Fund | 2026/Q3 | +143,339 | 2.1% |
| TCG Crossover Management, LLC | VC/PE Fund | 2026/Q3 | +71,224 | 3.0% |
| Longaeva Partners L.P. | Mutual Fund | 2026/Q3 | +55,834 | 0.8% |
| Driehaus Capital Management LLC | Mutual Fund | 2026/Q3 | +50,884 | 1.3% |
| Ikarian Capital, LLC | Hedge Fund | 2026/Q3 | +47,861 | 0.7% |
| BlackRock | Mutual Fund | 2026/Q3 | +32,252 | 5.2% |
| StemPoint Capital LP | Hedge Fund | 2026/Q3 | +30,125 | 0.4% |
| Boothbay Fund Management, LLC | Hedge Fund | 2026/Q3 | +14,689 | 0.2% |
| Neuberger Berman Investment Advisers LLC | Mutual Fund | 2026/Q3 | +12,760 | 0.8% |
| Geode Capital Management, LLC | Mutual Fund | 2026/Q3 | +12,660 | 1.7% |
| Ishara Investments, L.P. | Hedge Fund | 2026/Q3 | +12,300 | 0.2% |
| Trexquant Investment LP | Hedge Fund | 2026/Q3 | +12,004 | 0.2% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 30 Sep 2026 | Christopher Starr | Independent Executive Chairman of the Board | Derivative Exercise and Sale | -8,400 | $79.67 | 15,053 |
| 29 Sep 2026 | Andrew Cittadine | Chief Operating Officer | Derivative Exercise and Sale | -1,944 | $79.67 | 58,054 |
| 29 Sep 2026 | Andrew Cittadine | Chief Operating Officer | Derivative Exercise and Retained | +2,440 | – | 58,054 |
| 29 Sep 2026 | Chandler Robinson | Chief Executive Officer | Derivative Exercise and Sale | -4,344 | $79.67 | 167,539 |
| 29 Sep 2026 | Chandler Robinson | Chief Executive Officer | Derivative Exercise and Retained | +5,457 | – | 167,539 |
| 29 Sep 2026 | Quan Vu | CFO, Principal accounting officer & Principal financial officer | Derivative Exercise and Sale | -180 | $79.67 | 2,655 |
| 29 Sep 2026 | Quan Vu | CFO, Principal accounting officer & Principal financial officer | Derivative Exercise and Retained | +434 | – | 2,655 |
| 23 Sep 2026 | Chandler Robinson | Chief Executive Officer | Derivative Exercise and Sale | -29,056 | $89.79 | 162,082 |
| 25 Aug 2026 | Patrice Rioux | Acting Chief Medical Officer | Derivative Exercise and Sale | -1 | $111.26 | 5,065 |
| 25 Aug 2026 | Patrice Rioux | Acting Chief Medical Officer | Other Derivative Acquisition | +1,380 | $0.01 | – |
| 25 Aug 2026 | Patrice Rioux | Acting Chief Medical Officer | Derivative Exercise and Retained | +1,379 | $0.01 | 5,065 |
| 25 Aug 2026 | Kim Tsuchimoto | CFO, Secretary, Treasurer & Director | Automatic Disposition | -4,090 | $113.84 | 11,486 |
| 25 Aug 2026 | Kim Tsuchimoto | CFO, Secretary, Treasurer & Director | Derivative Exercise and Sale | -4,090 | $113.84 | 11,486 |
| 25 Aug 2026 | Kim Tsuchimoto | CFO, Secretary, Treasurer & Director | Other Derivative Acquisition | +4,090 | $30.00 | 8,140 |
| 24 Aug 2026 | Raymond Anderson | Independent Director | Derivative Exercise and Sale | -3,142 | $113.05 | 5,373 |
| 24 Aug 2026 | Raymond Anderson | Independent Director | Other Derivative Acquisition | +3,142 | $30.00 | 3,480 |
| 7 Jul 2026 | Arthur Klausner | Independent Director | Intent to Sell (Form 144) | -5,000 | – | – |
| 29 Jun 2026 | Andrew Cittadine | Chief Operating Officer | Derivative Exercise and Sale | -2,309 | $92.59 | 55,614 |
| 29 Jun 2026 | Andrew Cittadine | Chief Operating Officer | Derivative Exercise and Retained | +2,945 | – | 55,614 |
| 29 Jun 2026 | Chandler Robinson | Chief Executive Officer | Derivative Exercise and Sale | -4,084 | $92.59 | 162,082 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 844,226 | 12.6% | 7.2 |
| 31 Aug 2026 | 852,425 | 12.7% | 4.5 |
| 14 Aug 2026 | 887,188 | 13.2% | 3.5 |
| 31 Jul 2026 | 1,065,108 | 15.9% | 3.4 |
| 15 Jul 2026 | 1,360,286 | 20.3% | 5.9 |
| 30 Jun 2026 | 1,519,701 | 22.7% | 8.6 |
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