Stocks › Biotechnology › LXRX

Lexicon Pharmaceuticals LXRX

US equityMarket cap rank #3424Biotechnology

$1.76 +$0.01 (+0.57%)

Pre-market · Oct 8, 9:00 am ET · After hours $1.76 0.00%

Open$1.73

Prev close$1.75

Day range$1.71 – $1.77

Volume1.10M

Market cap$783.12M

P/E (TTM)–

Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership83.7%+0.12 pts vs. prior quarter

Institutions holding169+1 vs. prior quarter

Insider trades (recent)42 buys / 8 sellsNet buying

Short interest6.47% of floatDays to cover 13.4 · as of 15 Sep 2026

Short-sale volume share26.7%5-day average of daily volume

Short-sale volume as % of daily volume

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$3.16M (8 inflow days, 12 outflow days).

Net flow by order size, last 20 sessions

Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.

The five largest holders on file together own 71.7% of shares outstanding.

Largest holders

Artal Group S.A.49.32%
FMR11.64%
Sessa Capital IM, L.P.4.26%
BlackRock3.90%
Vanguard Capital Management, LLC2.59%
Point72 Asset Management, L.P.1.85%
Geode Capital Management, LLC1.40%
The Invus Group, LLC1.23%

By investor type

VC/PE Fund50.55%
Mutual Fund23.82%
Hedge Fund8.20%
Individual/Insider1.46%
Private Company0.49%
Public Company0.40%
Insurance Company0.12%
Government Pension Fund0.11%

Reported short interest has fallen from 6.93% to 6.47% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Recent institutional activity

Holder	Type	Period	Share change	New stake
Nuveen Asset Management LLC	Insurance Company	2026/Q3	+517,962	0.1%
Artal Group S.A.	VC/PE Fund	2026/Q3	+20,421,735	49.3%
BlackRock	Mutual Fund	2026/Q3	+14,026,522	3.9%
FMR	Mutual Fund	2026/Q3	+6,725,707	11.6%
State Street Global Advisors	Mutual Fund	2026/Q3	+3,953,731	1.1%
Geode Capital Management, LLC	Mutual Fund	2026/Q3	+3,075,261	1.4%
Vanguard Portfolio Management, LLC	Mutual Fund	2026/Q3	+1,811,149	0.5%
Northern Trust Global Investments	Mutual Fund	2026/Q3	+1,473,953	0.4%
Sessa Capital IM, L.P.	Hedge Fund	2026/Q3	+1,047,875	4.3%
Vanguard Capital Management, LLC	Mutual Fund	2026/Q3	+684,328	2.6%
Charles Schwab Investment Management	Mutual Fund	2026/Q3	+645,477	0.4%
BNY Mellon Asset Management	Mutual Fund	2026/Q3	+541,247	0.1%
Teachers Insurance and Annuity Association-College Retirement Equities Fund	Mutual Fund	2026/Q3	+522,727	0.1%
Citadel Advisors LLC	Hedge Fund	2026/Q3	+506,281	0.4%
Point72 Asset Management, L.P.	Hedge Fund	2026/Q3	+436,719	1.9%

Institutional buy/sell activity by reporting period, largest moves first.

Insider transactions

Date	Insider	Title	Transaction	Shares	Price	Held after
2 Jun 2026	Raymond Debbane	Independent Chairperson	Derivative Exercise and Retained	+89,312	–	1,995,498
2 Jun 2026	Samuel Barker	Independent Director	Derivative Exercise and Retained	+89,312	–	213,771
2 Jun 2026	Philippe Amouyal	Independent Director	Derivative Exercise and Retained	+89,312	–	374,486
2 Jun 2026	Christopher Sobecki	Independent Director	Derivative Exercise and Retained	+89,312	–	293,177
2 Jun 2026	Judith Swain	Independent Director	Derivative Exercise and Retained	+89,312	–	174,486
2 Jun 2026	Diane Sullivan	Director	Derivative Exercise and Retained	+89,312	–	126,122
2 Jun 2026	Ivan H. Cheung	Director	Derivative Exercise and Retained	+89,312	–	89,312
30 Apr 2026	Raymond Debbane	Independent Chairperson	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Raymond Debbane	Independent Chairperson	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Samuel Barker	Independent Director	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Samuel Barker	Independent Director	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Philippe Amouyal	Independent Director	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Philippe Amouyal	Independent Director	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Christopher Sobecki	Independent Director	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Christopher Sobecki	Independent Director	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Judith Swain	Independent Director	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Judith Swain	Independent Director	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Diane Sullivan	Director	Other Derivative Acquisition	+35,714	–	35,714
30 Apr 2026	Diane Sullivan	Director	Other Derivative Acquisition	+43,478	$1.61	43,478
30 Apr 2026	Ivan H. Cheung	Director	Other Derivative Acquisition	+35,714	–	35,714

From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.

Short interest, by report

Report date	Shares short	% of float	Days to cover
15 Sep 2026	28,793,507	6.5%	13.4
31 Aug 2026	29,490,809	6.6%	10.3
14 Aug 2026	32,749,669	7.4%	10.9
31 Jul 2026	32,825,365	7.4%	12.5
15 Jul 2026	32,730,919	7.4%	12.0
30 Jun 2026	30,784,601	6.9%	4.4

Discussion

No comments yet — be the first to weigh in on LXRX.