Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$8.29M (7 inflow days, 13 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 42.0% of shares outstanding.
Reported short interest has fallen from 17.00% to 16.66% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Troy Wilson | Individual/Insider | 2026/Q3 | +200,000 | 1.2% |
| Arrowstreet Capital, Limited Partnership | Mutual Fund | 2026/Q3 | +1,410,275 | 1.6% |
| AQR Capital Management | Hedge Fund | 2026/Q3 | +998,116 | 3.5% |
| BlackRock | Mutual Fund | 2026/Q3 | +871,702 | 11.8% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +817,317 | 6.0% |
| The Goldman Sachs Group, Inc. | Public Company | 2026/Q3 | +738,899 | 2.2% |
| Alethea Capital Management, LLC | Mutual Fund | 2026/Q3 | +638,569 | 2.4% |
| Royce & Associates, LP | Mutual Fund | 2026/Q3 | +605,042 | 0.7% |
| Jupiter Fund Management Plc | Mutual Fund | 2026/Q3 | +509,886 | 0.6% |
| Jacobs Levy Equity Management Inc | Mutual Fund | 2026/Q3 | +346,743 | 1.1% |
| Rhenman & Partners Asset Management AB | Hedge Fund | 2026/Q3 | +320,000 | 0.7% |
| GW&K Investment Management, LLC | Mutual Fund | 2026/Q3 | +291,880 | 0.3% |
| Ally Bridge Group | VC/PE Fund | 2026/Q3 | +290,000 | 0.3% |
| Ishara Investments, L.P. | Hedge Fund | 2026/Q3 | +276,750 | 0.3% |
| Hennion & Walsh Asset Management, Inc. | Mutual Fund | 2026/Q3 | +233,633 | 0.6% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 28 Sep 2026 | Kathleen Ford | Chief Operating Officer | Automatic Disposition | -3,668 | $10.75 | 92,986 |
| 28 Sep 2026 | Brian Powl | Chief Commercial Officer | Intent to Sell (Form 144) | -15,430 | $10.61 | – |
| 28 Sep 2026 | Mollie Leoni | Executive Vice President of Clinical Development | Automatic Disposition | -28,802 | $10.75 | 41,251 |
| 28 Sep 2026 | Brian Powl | Chief Commercial Officer | Automatic Disposition | -23,430 | $10.75 | 20,181 |
| 27 Sep 2026 | Teresa Bair | Chief Legal Officer | Open Market Disposition | -8,442 | $10.50 | 73,408 |
| 27 Sep 2026 | Kathleen Ford | Chief Operating Officer | Open Market Disposition | -6,906 | $10.50 | 92,986 |
| 27 Sep 2026 | Brian Powl | Chief Commercial Officer | Open Market Disposition | -9,020 | $10.50 | 20,181 |
| 27 Sep 2026 | Mollie Leoni | Executive Vice President of Clinical Development | Open Market Disposition | -12,448 | $10.50 | 41,251 |
| 27 Sep 2026 | Thomas Doyle | Senior VP of Finance & Accounting | Open Market Disposition | -4,607 | $10.50 | 71,209 |
| 23 Sep 2026 | Francis Burrows | Senior Vice President of Translational Research | Derivative Exercise and Sale | -20,726 | $10.83 | 42,327 |
| 23 Sep 2026 | Francis Burrows | Senior Vice President of Translational Research | Derivative Exercise and Retained | +9,274 | $6.15 | 42,327 |
| 7 Sep 2026 | Jennifer Fulk | Chief Financial Officer | Other Derivative Acquisition | +450,000 | $12.52 | 450,000 |
| 23 Aug 2026 | Troy Wilson | Chairperson & CEO | Open Market Acquisition | +100,000 | $12.39 | 1,032,150 |
| 20 Aug 2026 | Brian Powl | Chief Commercial Officer | Open Market Disposition | -4,345 | $11.89 | 52,632 |
| 18 Aug 2026 | Teresa Bair | Chief Legal Officer | Automatic Disposition | -31,487 | $12.63 | 81,850 |
| 16 Aug 2026 | Troy Wilson | Chairperson & CEO | Open Market Acquisition | +100,000 | $11.12 | 932,150 |
| 17 Jun 2026 | Mollie Leoni | Executive Vice President of Clinical Development | Automatic Disposition | -84,929 | $9.82 | 82,500 |
| 3 Jun 2026 | Diane Parks | Independent Director | Other Derivative Acquisition | +35,000 | $8.77 | 35,000 |
| 3 Jun 2026 | Thomas Malley | Independent Director | Other Derivative Acquisition | +35,000 | $8.77 | 35,000 |
| 3 Jun 2026 | Mary Szela | Independent Director | Other Derivative Acquisition | +35,000 | $8.77 | 35,000 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 14,820,592 | 16.7% | 8.8 |
| 31 Aug 2026 | 13,417,317 | 15.1% | 4.8 |
| 14 Aug 2026 | 13,124,869 | 14.8% | 8.8 |
| 31 Jul 2026 | 13,160,945 | 14.8% | 11.8 |
| 15 Jul 2026 | 13,732,567 | 15.5% | 7.7 |
| 30 Jun 2026 | 15,092,162 | 17.0% | 8.6 |
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