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Edgewise Therapeutics EWTX

US equityMarket cap rank #2209Biotechnology
$40.30 −$1.10 (-2.66%)
Market closed · Oct 5, 10:20 pm ET · Last extended-hours $40.30 0.00%
Open$41.55
Prev close$41.40
Day range$39.98 – $41.79
Volume1.63M
Market cap$4.38B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership111.1%-1.23 pts vs. prior quarter
Institutions holding281-3 vs. prior quarter
Insider trades (recent)35 buys / 15 sellsNet buying
Short interest8.79% of floatDays to cover 8.0 · as of 15 Sep 2026
Short-sale volume share18.0%5-day average of daily volume

Short-sale volume as % of daily volume

9%15%20%25%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$7.56M (9 inflow days, 11 outflow days).

The five largest holders on file together own 43.1% of shares outstanding.

Largest holders

  • OrbiMed Advisors LLC14.29%
  • Paradigm Biocapital Advisors LP9.41%
  • RA Capital Management, L.P.7.73%
  • BlackRock6.08%
  • Janus Henderson Group plc5.59%
  • FMR5.05%
  • Novo Holdings A/S4.93%
  • Driehaus Capital Management LLC4.35%

By investor type

  • Mutual Fund45.42%
  • VC/PE Fund35.91%
  • Hedge Fund23.86%
  • Public Company4.25%
  • Government Pension Fund0.59%
  • Sovereign Wealth Fund0.48%
  • Private Company0.38%
  • Individual/Insider0.19%

Reported short interest has fallen from 9.75% to 8.79% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 9,543,843 8.8% 8.0
31 Aug 2026 9,346,141 8.6% 8.0
14 Aug 2026 9,675,389 8.9% 6.4
31 Jul 2026 9,835,054 9.1% 12.1
15 Jul 2026 10,074,332 9.4% 8.3
30 Jun 2026 10,492,798 9.8% 5.0

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