Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: +$2.08M (4 inflow days, 16 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 52.9% of shares outstanding.
Reported short interest has held roughly steady near 2.15% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| BlackRock | Mutual Fund | 2026/Q3 | +48,556 | 0.7% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +20,536 | 0.1% |
| JPMorgan Chase & Co. | Public Company | 2026/Q3 | +3,602,577 | 13.4% |
| MPM BioImpact LLC | VC/PE Fund | 2026/Q3 | +3,044,658 | 11.3% |
| RA Capital Management, L.P. | VC/PE Fund | 2026/Q3 | +7,315,288 | 12.4% |
| Logos Global Management, L.P. | Hedge Fund | 2026/Q3 | +915,000 | 1.5% |
| Morgan Stanley | Public Company | 2026/Q3 | +808,792 | 1.6% |
| Perceptive Advisors LLC | VC/PE Fund | 2026/Q3 | +688,959 | 2.8% |
| Patient Square Capital, LP | VC/PE Fund | 2026/Q3 | +215,940 | 1.5% |
| Jane Street Group, LLC | Private Company | 2026/Q3 | +212,630 | 0.4% |
| Great Point Partners, LLC | VC/PE Fund | 2026/Q3 | +156,906 | 0.3% |
| Columbia Management Investment Advisers, LLC | Mutual Fund | 2026/Q3 | +147,080 | 0.6% |
| Hudson River Trading LLC | Private Company | 2026/Q3 | +127,112 | 0.3% |
| Ishara Investments, L.P. | Hedge Fund | 2026/Q3 | +82,000 | 0.3% |
| Deutsche Asset & Wealth Management | Mutual Fund | 2026/Q3 | +59,240 | 0.1% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 28 Jul 2026 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -464 | $2.70 | 53,344 |
| 28 Jan 2026 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -534 | $4.86 | 50,370 |
| 11 Jan 2026 | Julian Baker | Other Derivative Acquisition | +27,304,896 | – | 25,005,240 | |
| 17 Dec 2025 | Bpifrance Participations SA | Private Disposition | -3,369,093 | $5.28 | 7,529,502 | |
| 20 Nov 2025 | Daniel Tassé | Chief Executive Officer | Other Derivative Acquisition | +964,000 | $2.90 | 964,000 |
| 20 Nov 2025 | Virginie Simone Jeanine Boucinha | Chief Financial Officer | Other Acquisition | +32,000 | – | 55,750 |
| 20 Nov 2025 | Virginie Simone Jeanine Boucinha | Chief Financial Officer | Other Derivative Acquisition | +192,000 | $2.90 | 192,000 |
| 20 Nov 2025 | Pharis Mohideen | Chief Medical Officer | Other Acquisition | +44,000 | – | 95,713 |
| 20 Nov 2025 | Pharis Mohideen | Chief Medical Officer | Other Derivative Acquisition | +253,000 | $2.90 | 253,000 |
| 20 Nov 2025 | Kevin Trapp | Former Chief Commercial Officer | Other Acquisition | +55,000 | – | 55,000 |
| 20 Nov 2025 | Kevin Trapp | Former Chief Commercial Officer | Other Derivative Acquisition | +316,250 | $2.90 | 316,250 |
| 20 Nov 2025 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -8,120 | $2.88 | 49,817 |
| 28 Jul 2025 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -464 | $2.22 | 38,249 |
| 21 May 2025 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -397 | $1.84 | 37,463 |
| 26 Mar 2025 | Julian Baker | Other Derivative Acquisition | +27,304,896 | – | 25,005,240 | |
| 26 Mar 2025 | Bpifrance Participations SA | Initial Statement of Beneficial | +0 | – | 6,556,781 | |
| 26 Mar 2025 | EPIC Bpifrance, Asset Management Arm | Initial Statement of Beneficial | +0 | – | – | |
| 29 Jan 2025 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -600 | $0.85 | 34,585 |
| 3 Dec 2024 | Daniel Tassé | Chief Executive Officer | Other Derivative Acquisition | +813,200 | $0.89 | 813,200 |
| 24 Nov 2024 | Pharis Mohideen | Chief Medical Officer | Private Disposition | -565 | $0.57 | 33,935 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 1,353,244 | 2.2% | 3.3 |
| 31 Aug 2026 | 1,583,924 | 2.5% | 9.7 |
| 14 Aug 2026 | 1,633,383 | 2.6% | 4.0 |
| 31 Jul 2026 | 1,848,774 | 3.1% | 5.0 |
| 15 Jul 2026 | 1,470,719 | 2.5% | 7.8 |
| 30 Jun 2026 | 1,299,136 | 2.2% | 3.7 |
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