Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: +$420.5K (13 inflow days, 7 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 37.8% of shares outstanding.
Reported short interest has fallen from 4.88% to 4.72% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Novo Holdings A/S | VC/PE Fund | 2026/Q3 | +3,883,289 | 8.8% |
| FMR | Mutual Fund | 2026/Q3 | +3,550,724 | 8.0% |
| T. Rowe Price Group, Inc. | Mutual Fund | 2026/Q3 | +3,337,976 | 7.5% |
| SR One Capital Management, LP | VC/PE Fund | 2026/Q3 | +3,308,649 | 7.5% |
| Perceptive Advisors LLC | VC/PE Fund | 2026/Q3 | +2,675,296 | 6.0% |
| Montanova Capital, LLC | Hedge Fund | 2026/Q3 | +2,503,109 | 5.6% |
| Impresa Management LLC | VC/PE Fund | 2026/Q3 | +2,284,535 | 5.2% |
| NVP Associates, LLC | VC/PE Fund | 2026/Q3 | +2,268,404 | 5.1% |
| Wellington Management Group | Mutual Fund | 2026/Q3 | +2,201,986 | 5.0% |
| Catalio Capital Management, LP | VC/PE Fund | 2026/Q3 | +1,675,830 | 3.8% |
| Eventide Asset Management, LLC | Mutual Fund | 2026/Q3 | +1,375,486 | 3.1% |
| Bellevue Asset Management AG | Mutual Fund | 2026/Q3 | +1,350,000 | 3.0% |
| BlackRock | Mutual Fund | 2026/Q3 | +977,264 | 2.2% |
| Pivotal BioVenture Partners LLC | VC/PE Fund | 2026/Q3 | +966,792 | 2.2% |
| Citadel Advisors LLC | Hedge Fund | 2026/Q3 | +959,098 | 2.2% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 14 Sep 2026 | Robert Meyer | Director | Other Derivative Acquisition | +31,182 | $34.28 | 31,182 |
| 30 Apr 2026 | Wellington Management Group | Derivative Exercise and Retained | +1,275,486 | – | 1,275,486 | |
| 30 Apr 2026 | Novo Holdings A/S | Private Acquisition | +555,555 | $18.00 | 3,883,289 | |
| 30 Apr 2026 | Novo Holdings A/S | Derivative Exercise and Retained | +3,327,734 | – | 3,883,289 | |
| 30 Apr 2026 | Impresa Management LLC | Derivative Exercise and Retained | +2,284,535 | – | 2,284,535 | |
| 30 Apr 2026 | SR One Capital Management, LP | Private Acquisition | +555,555 | $18.00 | 3,308,649 | |
| 30 Apr 2026 | SR One Capital Management, LP | Derivative Exercise and Retained | +2,753,094 | – | 3,308,649 | |
| 29 Apr 2026 | Douglas Carlson | CFO & Chief Business Officer | Other Derivative Acquisition | +211,975 | $18.00 | 211,975 |
| 29 Apr 2026 | Erin Lavelle | Independent Director | Other Derivative Acquisition | +26,978 | $18.00 | 26,978 |
| 28 Apr 2026 | Novo Holdings A/S | Initial Statement of Beneficial | +0 | – | 652,649 | |
| 28 Apr 2026 | Douglas Carlson | CFO & Chief Business Officer | Initial Statement of Beneficial | +0 | – | 354,074 |
| 28 Apr 2026 | Heather Turner | Independent Chairperson | Other Derivative Acquisition | +26,978 | $18.00 | 26,978 |
| 28 Apr 2026 | Heather Turner | Independent Chairperson | Initial Statement of Beneficial | +0 | – | 64,919 |
| 28 Apr 2026 | Lyn Baranowski | Chief Executive Officer | Other Derivative Acquisition | +501,033 | $18.00 | 501,033 |
| 28 Apr 2026 | Lyn Baranowski | Chief Executive Officer | Initial Statement of Beneficial | +0 | – | 1,499,081 |
| 28 Apr 2026 | Kathryn Haviland | Independent Director | Other Derivative Acquisition | +26,978 | $18.00 | 26,978 |
| 28 Apr 2026 | Kathryn Haviland | Independent Director | Initial Statement of Beneficial | +0 | – | 43,928 |
| 28 Apr 2026 | Jon Congleton | Independent Director | Other Derivative Acquisition | +26,978 | $18.00 | 26,978 |
| 28 Apr 2026 | Jon Congleton | Independent Director | Initial Statement of Beneficial | +0 | – | 43,928 |
| 28 Apr 2026 | Erin Lavelle | Independent Director | Initial Statement of Beneficial | +0 | – | 43,928 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 2,093,252 | 4.7% | 9.6 |
| 31 Aug 2026 | 1,930,246 | 4.4% | 11.3 |
| 14 Aug 2026 | 2,072,596 | 4.7% | 10.9 |
| 31 Jul 2026 | 2,018,998 | 4.6% | 9.4 |
| 15 Jul 2026 | 2,190,330 | 4.9% | 5.6 |
| 30 Jun 2026 | 2,165,545 | 4.9% | 3.1 |
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