Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: +$1.67M (11 inflow days, 9 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 37.2% of shares outstanding.
Reported short interest has risen from 5.18% to 6.87% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Balyasny Asset Management L.P. | Hedge Fund | 2026/Q3 | +2,183,822 | 4.8% |
| Point72 Asset Management, L.P. | Hedge Fund | 2026/Q3 | +2,140,664 | 3.3% |
| MPM BioImpact LLC | VC/PE Fund | 2026/Q3 | +1,936,291 | 3.0% |
| Perceptive Advisors LLC | VC/PE Fund | 2026/Q3 | +1,793,190 | 2.8% |
| Cormorant Asset Management, LP | Hedge Fund | 2026/Q3 | +1,080,372 | 6.2% |
| Octagon Capital Advisors LP | Hedge Fund | 2026/Q3 | +934,716 | 1.5% |
| ADAR1 Capital Management, LLC | Hedge Fund | 2026/Q3 | +899,896 | 1.6% |
| Braidwell LP | Hedge Fund | 2026/Q3 | +795,214 | 1.2% |
| Eventide Asset Management, LLC | Mutual Fund | 2026/Q3 | +718,747 | 1.1% |
| Casdin Capital, LLC | VC/PE Fund | 2026/Q3 | +711,539 | 1.9% |
| Soleus Capital Management, L.P. | Hedge Fund | 2026/Q3 | +405,523 | 0.6% |
| Freestone Grove Partners LP | Hedge Fund | 2026/Q3 | +397,446 | 0.6% |
| Boone Capital Management LLC | Hedge Fund | 2026/Q3 | +258,390 | 0.4% |
| Woodline Partners LP | Hedge Fund | 2026/Q3 | +246,474 | 0.7% |
| Dafna Capital Management, LLC | Hedge Fund | 2026/Q3 | +239,553 | 0.4% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 29 Sep 2026 | Ping Ji | Director | Open Market Disposition | -10,214 | $16.03 | 121,453 |
| 28 Sep 2026 | Ping Ji | Director | Intent to Sell (Form 144) | -80,000 | $15.28 | – |
| 21 Sep 2026 | Ping Ji | Director | Open Market Disposition | -5,000 | $16.63 | 131,667 |
| 25 Aug 2026 | Xiaofeng Ye | Interim CFO and VP of Business Development & Commercialization Strategy | Open Market Disposition | -11,667 | $14.25 | 147,788 |
| 9 Jun 2026 | Ping Ji | Director | Other Acquisition | +136,667 | – | 136,667 |
| 27 May 2026 | Xiaofeng Ye | Interim CFO and VP of Business Development & Commercialization Strategy | Initial Statement of Beneficial | +0 | – | 94,251 |
| 12 May 2026 | Yang Lu | Chairperson & CEO | Open Market Disposition | -10 | $13.18 | 99,990 |
| 17 Mar 2026 | Roger Sawhney | Director | Initial Statement of Beneficial | +0 | – | 8,162 |
| 17 Mar 2026 | Ngai Chiu Tse | Head of Research & Development | Initial Statement of Beneficial | +0 | – | 50,000 |
| 17 Mar 2026 | Lars Erik Birgerson | Director | Initial Statement of Beneficial | +0 | – | 166,668 |
| 17 Mar 2026 | Yang Lu | Chairperson & CEO | Initial Statement of Beneficial | +0 | – | 100,000 |
| 17 Mar 2026 | Nortye International Limited , ESOP | Initial Statement of Beneficial | +0 | – | 16,990,000 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 4,422,982 | 6.9% | 22.2 |
| 31 Aug 2026 | 4,121,776 | 6.4% | 26.8 |
| 14 Aug 2026 | 4,296,438 | 6.7% | 26.3 |
| 31 Jul 2026 | 4,174,500 | 6.5% | 18.5 |
| 15 Jul 2026 | 3,518,214 | 5.5% | 14.6 |
| 30 Jun 2026 | 3,335,395 | 5.2% | 23.1 |
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