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Amylyx Pharmaceuticals AMLX

US equityMarket cap rank #2376
$27.78 −$0.01 (-0.04%)
Market closed · Oct 6, 12:40 am ET · Last extended-hours $28.56 +2.81%
Open$27.92
Prev close$27.79
Day range$27.34 – $28.09
Volume941.1K
Market cap$3.49B
P/E (TTM)–
Dividend yield–

Ownership & positioning

Who holds it, who is betting against it, and where the big money is moving

Institutional ownership91.8%-14.89 pts vs. prior quarter
Institutions holding237-2 vs. prior quarter
Insider trades (recent)24 buys / 26 sellsNet selling
Short interest12.13% of floatDays to cover 8.6 · as of 15 Sep 2026
Short-sale volume share17.4%5-day average of daily volume

Short-sale volume as % of daily volume

12%21%31%40%Sep '26Sep '26Oct '26

Large-order net flow, last 20 sessions

Net of large-order buying minus selling, in USD. Over this window: −$5.79M (7 inflow days, 13 outflow days).

The five largest holders on file together own 36.5% of shares outstanding.

Largest holders

  • FMR13.33%
  • BlackRock7.03%
  • Perceptive Advisors LLC6.64%
  • TCG Crossover Management, LLC4.97%
  • Commodore Capital LP4.50%
  • Janus Henderson Group plc4.17%
  • Vanguard Capital Management, LLC3.86%
  • Saturn V Capital Management LP3.68%

By investor type

  • Mutual Fund52.37%
  • Hedge Fund20.04%
  • VC/PE Fund13.50%
  • Individual/Insider6.08%
  • Public Company4.50%
  • Private Company0.92%
  • Government Pension Fund0.23%
  • Sovereign Wealth Fund0.13%

Reported short interest has fallen from 12.94% to 12.13% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).

Short interest, by report

Report dateShares short% of floatDays to cover
15 Sep 2026 13,512,753 12.1% 8.6
31 Aug 2026 12,737,201 11.4% 2.4
14 Aug 2026 13,425,106 12.0% 7.1
31 Jul 2026 13,401,722 12.1% 6.8
15 Jul 2026 12,265,993 11.0% 9.2
30 Jun 2026 14,385,180 12.9% 7.1

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