Who holds it, who is betting against it, and where the big money is moving
Net of large-order buying minus selling, in USD. Over this window: −$724.1K (9 inflow days, 11 outflow days).
Super/Big orders approximate institutional-size trades; Mid/Small approximate retail-size trades. Net buy minus sell value in each bucket, summed over the window.
The five largest holders on file together own 46.7% of shares outstanding.
Reported short interest has fallen from 5.98% to 5.85% of float over the last 6 biweekly reports (30 Jun 2026 to 15 Sep 2026).
| Holder | Type | Period | Share change | New stake |
|---|---|---|---|---|
| Nuveen Asset Management LLC | Insurance Company | 2026/Q3 | +41,719 | 0.1% |
| TCG Crossover Management, LLC | VC/PE Fund | 2026/Q3 | +696,560 | 1.3% |
| BlackRock | Mutual Fund | 2026/Q3 | +166,231 | 4.1% |
| Barclays PLC | Public Company | 2026/Q3 | +146,282 | 0.3% |
| Renaissance Technologies Corp. | Hedge Fund | 2026/Q3 | +95,400 | 0.2% |
| Polen Capital Management, LLC | Mutual Fund | 2026/Q3 | +63,514 | 0.1% |
| Tidal Investments LLC | Mutual Fund | 2026/Q3 | +57,059 | 0.1% |
| State Street Global Advisors | Mutual Fund | 2026/Q3 | +55,757 | 0.9% |
| Raymond James Financial, Inc. | Public Company | 2026/Q3 | +50,464 | 0.1% |
| AQR Capital Management | Hedge Fund | 2026/Q3 | +47,504 | 0.1% |
| Quantinno Capital Management LP | Mutual Fund | 2026/Q3 | +46,887 | 0.1% |
| Great Lakes Advisors, LLC | Mutual Fund | 2026/Q3 | +43,612 | 0.1% |
| Mirador Capital Partners, LP | Mutual Fund | 2026/Q3 | +40,124 | 0.1% |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Private Company | 2026/Q3 | +39,308 | 0.1% |
| Squarepoint OPS LLC | Hedge Fund | 2026/Q3 | +38,381 | 0.1% |
Institutional buy/sell activity by reporting period, largest moves first.
| Date | Insider | Title | Transaction | Shares | Price | Held after |
|---|---|---|---|---|---|---|
| 22 Sep 2026 | Akos Czibere | Chief Medical Officer | Derivative Exercise and Sale | -12,500 | $21.03 | – |
| 19 Jul 2026 | Ken Herrmann | Chair of Scientific Advisory Board & Independent Director | Derivative Exercise and Sale | -4,856 | $24.56 | – |
| 16 Jul 2026 | Ken Herrmann | Chair of Scientific Advisory Board & Independent Director | Derivative Exercise and Sale | -3,065 | $25.21 | – |
| 7 Jul 2026 | Shulamit Ron-Bigger | Chief Operating Officer | Derivative Exercise and Sale | -50,000 | $28.75 | – |
| 7 Jul 2026 | Akos Czibere | Chief Medical Officer | Derivative Exercise and Sale | -50,000 | $28.71 | – |
| 11 Jan 2026 | MPM BioImpact LLC | Private Acquisition | +1,112,777 | $18.00 | 10,260,064 | |
| 11 Jan 2026 | MPM BioImpact LLC | Derivative Exercise and Retained | +8,208,187 | – | 10,260,064 | |
| 11 Jan 2026 | Eli Lilly and Company | Initial Statement of Beneficial | +0 | – | 6,344,114 | |
| 11 Jan 2026 | Lloyd Segal | Independent Director | Derivative Exercise and Retained | +19,631 | – | 19,631 |
| 11 Jan 2026 | EcoR1 Capital, LLC | Private Acquisition | +2,222,222 | $18.00 | 4,824,469 | |
| 11 Jan 2026 | EcoR1 Capital, LLC | Derivative Exercise and Retained | +2,602,247 | – | 4,824,469 | |
| 11 Jan 2026 | Vida Ventures Advisors, LLC | Private Acquisition | +835,000 | $18.00 | 5,829,212 | |
| 11 Jan 2026 | Vida Ventures Advisors, LLC | Derivative Exercise and Retained | +4,994,212 | – | 5,829,212 | |
| 7 Jan 2026 | MPM BioImpact LLC | Initial Statement of Beneficial | +0 | – | 597,393 | |
| 7 Jan 2026 | Todd Foley | Chairperson | Initial Statement of Beneficial | +0 | – | 37,866 |
| 7 Jan 2026 | Helen Kim | Independent Director | Initial Statement of Beneficial | +0 | – | 37,866 |
| 7 Jan 2026 | Michael Sherman | Independent Director | Initial Statement of Beneficial | +0 | – | 93,846 |
| 7 Jan 2026 | Lloyd Segal | Independent Director | Initial Statement of Beneficial | +0 | – | 6,489 |
| 7 Jan 2026 | Mary Thistle | Independent Director | Initial Statement of Beneficial | +0 | – | 93,846 |
| 7 Jan 2026 | Matthew Roden | Chief Executive Officer | Initial Statement of Beneficial | +0 | – | 2,149,409 |
From Form 4/Form 144 filings. Negative share counts are disposals (sales, gifts, or shares withheld for taxes); positive are acquisitions.
| Report date | Shares short | % of float | Days to cover |
|---|---|---|---|
| 15 Sep 2026 | 3,252,475 | 5.8% | 11.5 |
| 31 Aug 2026 | 3,175,040 | 5.7% | 10.4 |
| 14 Aug 2026 | 3,447,126 | 6.2% | 15.0 |
| 31 Jul 2026 | 3,470,122 | 6.3% | 12.8 |
| 15 Jul 2026 | 3,741,161 | 6.8% | 6.3 |
| 30 Jun 2026 | 3,306,972 | 6.0% | 5.0 |
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